Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1130

Experiment: 7H9 with Benzethonium chloride 0.068 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1129c and Rv1130 are separated by 20 nucleotidesRv1130 and Rv1131 overlap by 4 nucleotides Rv1129c: Rv1129c - Probable transcriptional regulator protein, at 1,253,074 to 1,254,534 Rv1129c Rv1130: Rv1130 - Possible methylcitrate dehydratase PrpD, at 1,254,555 to 1,256,135 Rv1130 Rv1131: Rv1131 - Probable methylcitrate synthase PrpC, at 1,256,132 to 1,257,313 Rv1131 Position (kb) 1254 1255 1256 1257Strain fitness (log2 ratio) -1 0 1at 1253.995 kb on - strand, within Rv1129cat 1254.033 kb on - strand, within Rv1129cat 1254.312 kb on - strand, within Rv1129cat 1254.398 kb on + strandat 1254.398 kb on + strandat 1254.398 kb on + strandat 1254.398 kb on + strandat 1254.498 kb on - strandat 1254.522 kb on + strandat 1254.697 kb on - strandat 1254.697 kb on - strandat 1254.994 kb on + strand, within Rv1130at 1254.994 kb on + strand, within Rv1130at 1255.198 kb on - strand, within Rv1130at 1255.467 kb on + strand, within Rv1130at 1255.598 kb on - strand, within Rv1130at 1255.598 kb on - strand, within Rv1130at 1255.678 kb on - strand, within Rv1130at 1256.810 kb on + strand, within Rv1131at 1256.811 kb on - strand, within Rv1131at 1257.072 kb on - strand, within Rv1131

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Benzethonium chloride 0.068 mM
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1,253,995 - Rv1129c 0.63 -0.5
1,254,033 - Rv1129c 0.66 -0.8
1,254,312 - Rv1129c 0.85 +0.1
1,254,398 + +0.2
1,254,398 + -0.3
1,254,398 + -1.3
1,254,398 + -0.8
1,254,498 - +0.3
1,254,522 + -1.0
1,254,697 - +0.0
1,254,697 - -1.4
1,254,994 + Rv1130 0.28 -0.0
1,254,994 + Rv1130 0.28 +1.7
1,255,198 - Rv1130 0.41 +0.2
1,255,467 + Rv1130 0.58 +0.4
1,255,598 - Rv1130 0.66 +0.8
1,255,598 - Rv1130 0.66 +0.4
1,255,678 - Rv1130 0.71 +0.2
1,256,810 + Rv1131 0.57 -0.4
1,256,811 - Rv1131 0.57 -0.6
1,257,072 - Rv1131 0.80 +0.2

Or see this region's nucleotide sequence