Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1493

Experiment: 7H9 with Spectinomycin 0.029 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1492 and Rv1493 are separated by 0 nucleotidesRv1493 and Rv1494 are separated by 13 nucleotidesRv1494 and Rv1495 overlap by 4 nucleotidesRv1495 and Rv1496 overlap by 4 nucleotides Rv1492: Rv1492 - Probable methylmalonyl-CoA mutase small subunit MutA (MCM), at 1,682,157 to 1,684,004 Rv1492 Rv1493: Rv1493 - Probable methylmalonyl-CoA mutase large subunit MutB (MCM), at 1,684,005 to 1,686,257 Rv1493 Rv1494: Rv1494 - Possible antitoxin MazE4, at 1,686,271 to 1,686,573 Rv1494 Rv1495: Rv1495 - Possible toxin MazF4, at 1,686,570 to 1,686,887 Rv1495 Rv1496: Rv1496 - Possible transport system kinase, at 1,686,884 to 1,687,888 Rv1496 Position (kb) 1684 1685 1686 1687Strain fitness (log2 ratio) -2 -1 0 1 2 3at 1683.008 kb on - strand, within Rv1492at 1683.508 kb on - strand, within Rv1492at 1683.508 kb on - strand, within Rv1492at 1683.613 kb on + strand, within Rv1492at 1683.885 kb on + strandat 1683.885 kb on + strandat 1684.188 kb on + strandat 1684.188 kb on + strandat 1684.188 kb on + strandat 1684.188 kb on + strandat 1684.188 kb on + strandat 1684.189 kb on - strandat 1684.288 kb on - strand, within Rv1493at 1684.585 kb on - strand, within Rv1493at 1684.585 kb on - strand, within Rv1493at 1684.680 kb on + strand, within Rv1493at 1684.681 kb on - strand, within Rv1493at 1684.686 kb on + strand, within Rv1493at 1684.687 kb on - strand, within Rv1493at 1684.848 kb on + strand, within Rv1493at 1685.031 kb on - strand, within Rv1493at 1685.271 kb on + strand, within Rv1493at 1685.271 kb on + strand, within Rv1493at 1685.271 kb on + strand, within Rv1493at 1685.275 kb on - strand, within Rv1493at 1685.460 kb on + strand, within Rv1493at 1685.649 kb on - strand, within Rv1493at 1685.727 kb on + strand, within Rv1493at 1685.727 kb on + strand, within Rv1493at 1685.727 kb on + strand, within Rv1493at 1685.728 kb on - strand, within Rv1493at 1685.728 kb on - strand, within Rv1493at 1685.728 kb on - strand, within Rv1493at 1686.243 kb on + strandat 1686.243 kb on + strandat 1686.371 kb on - strand, within Rv1494at 1686.440 kb on + strand, within Rv1494at 1686.466 kb on + strand, within Rv1494at 1686.497 kb on - strand, within Rv1494at 1686.502 kb on + strand, within Rv1494at 1686.503 kb on - strand, within Rv1494at 1686.713 kb on - strand, within Rv1495at 1686.875 kb on - strandat 1687.207 kb on + strand, within Rv1496at 1687.207 kb on + strand, within Rv1496

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Spectinomycin 0.029 mM
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1,683,008 - Rv1492 0.46 +0.2
1,683,508 - Rv1492 0.73 -0.2
1,683,508 - Rv1492 0.73 -0.3
1,683,613 + Rv1492 0.79 -1.4
1,683,885 + -0.1
1,683,885 + +2.7
1,684,188 + +0.3
1,684,188 + -0.2
1,684,188 + +2.9
1,684,188 + -0.9
1,684,188 + +0.3
1,684,189 - -0.2
1,684,288 - Rv1493 0.13 -0.3
1,684,585 - Rv1493 0.26 +0.2
1,684,585 - Rv1493 0.26 -0.4
1,684,680 + Rv1493 0.30 -0.5
1,684,681 - Rv1493 0.30 -1.2
1,684,686 + Rv1493 0.30 -0.4
1,684,687 - Rv1493 0.30 -0.8
1,684,848 + Rv1493 0.37 +1.9
1,685,031 - Rv1493 0.46 -0.1
1,685,271 + Rv1493 0.56 -0.7
1,685,271 + Rv1493 0.56 -1.7
1,685,271 + Rv1493 0.56 -0.6
1,685,275 - Rv1493 0.56 -0.3
1,685,460 + Rv1493 0.65 -0.1
1,685,649 - Rv1493 0.73 +1.3
1,685,727 + Rv1493 0.76 +0.1
1,685,727 + Rv1493 0.76 -0.7
1,685,727 + Rv1493 0.76 -1.9
1,685,728 - Rv1493 0.76 +0.5
1,685,728 - Rv1493 0.76 -0.0
1,685,728 - Rv1493 0.76 -0.5
1,686,243 + -0.1
1,686,243 + -0.0
1,686,371 - Rv1494 0.33 -1.1
1,686,440 + Rv1494 0.56 -0.4
1,686,466 + Rv1494 0.64 -0.2
1,686,497 - Rv1494 0.75 +0.8
1,686,502 + Rv1494 0.76 -0.1
1,686,503 - Rv1494 0.77 +0.1
1,686,713 - Rv1495 0.45 -0.5
1,686,875 - -0.0
1,687,207 + Rv1496 0.32 +0.6
1,687,207 + Rv1496 0.32 -0.5

Or see this region's nucleotide sequence