Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0456B

Experiment: 7H9 with Erythromycin 0.016 mM

Add experiment(s):

Zoom: Pan:

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

download SVG
500 ntRv0456c and Rv0456A are separated by 272 nucleotidesRv0456A and Rv0456B overlap by 14 nucleotidesRv0456B and Rv0457c are separated by 68 nucleotides Rv0456c: Rv0456c - enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 545,889 to 546,803 Rv0456c Rv0456A: Rv0456A - Possible toxin MazF1, at 547,076 to 547,357 Rv0456A Rv0456B: Rv0456B - Possible antitoxin MazE1, at 547,344 to 547,517 Rv0456B Rv0457c: Rv0457c - Probable peptidase, at 547,586 to 549,607 Rv0457c Position (kb) 547 548Strain fitness (log2 ratio) -1 0 1 2at 546.352 kb on + strand, within Rv0456cat 546.352 kb on + strand, within Rv0456cat 546.601 kb on + strand, within Rv0456cat 546.772 kb on + strandat 546.772 kb on + strandat 546.772 kb on + strandat 546.773 kb on - strandat 546.803 kb on + strandat 546.804 kb on - strandat 547.036 kb on + strandat 547.036 kb on + strandat 547.036 kb on + strandat 547.037 kb on - strandat 547.245 kb on - strand, within Rv0456Aat 547.360 kb on - strandat 547.474 kb on - strand, within Rv0456Bat 547.481 kb on + strand, within Rv0456Bat 547.481 kb on + strand, within Rv0456Bat 547.482 kb on - strand, within Rv0456Bat 547.482 kb on - strand, within Rv0456Bat 547.482 kb on - strand, within Rv0456Bat 547.482 kb on - strand, within Rv0456Bat 547.484 kb on + strand, within Rv0456Bat 547.491 kb on + strand, within Rv0456Bat 547.492 kb on - strand, within Rv0456Bat 547.494 kb on + strand, within Rv0456Bat 547.497 kb on + strand, within Rv0456Bat 547.497 kb on + strand, within Rv0456Bat 547.505 kb on - strandat 547.507 kb on + strandat 547.515 kb on - strandat 547.690 kb on - strandat 547.787 kb on + strandat 547.787 kb on + strandat 547.879 kb on - strand, within Rv0457cat 548.178 kb on + strand, within Rv0457cat 548.179 kb on - strand, within Rv0457cat 548.179 kb on - strand, within Rv0457cat 548.224 kb on - strand, within Rv0457cat 548.313 kb on + strand, within Rv0457cat 548.357 kb on + strand, within Rv0457c

download strain data

Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Erythromycin 0.016 mM
remove
546,352 + Rv0456c 0.51 -0.2
546,352 + Rv0456c 0.51 +2.1
546,601 + Rv0456c 0.78 -1.0
546,772 + +0.6
546,772 + +1.3
546,772 + -1.5
546,773 - -0.6
546,803 + +1.6
546,804 - -0.6
547,036 + -0.1
547,036 + -0.7
547,036 + -0.4
547,037 - +0.7
547,245 - Rv0456A 0.60 -1.7
547,360 - +0.4
547,474 - Rv0456B 0.75 +2.4
547,481 + Rv0456B 0.79 -0.1
547,481 + Rv0456B 0.79 +0.2
547,482 - Rv0456B 0.79 +0.5
547,482 - Rv0456B 0.79 +0.1
547,482 - Rv0456B 0.79 -0.9
547,482 - Rv0456B 0.79 +0.2
547,484 + Rv0456B 0.80 -0.5
547,491 + Rv0456B 0.84 -0.8
547,492 - Rv0456B 0.85 +0.1
547,494 + Rv0456B 0.86 -0.0
547,497 + Rv0456B 0.88 +1.4
547,497 + Rv0456B 0.88 -0.0
547,505 - -0.1
547,507 + +1.4
547,515 - +0.3
547,690 - -0.5
547,787 + -0.3
547,787 + +0.4
547,879 - Rv0457c 0.14 +0.0
548,178 + Rv0457c 0.29 -0.3
548,179 - Rv0457c 0.29 +0.1
548,179 - Rv0457c 0.29 -1.0
548,224 - Rv0457c 0.32 +0.4
548,313 + Rv0457c 0.36 -0.6
548,357 + Rv0457c 0.38 -0.5

Or see this region's nucleotide sequence