Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1418

Experiment: no stress control

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1415 and Rv1416 overlap by 4 nucleotidesRv1416 and Rv1417 overlap by 4 nucleotidesRv1417 and Rv1418 are separated by 24 nucleotidesRv1418 and Rv1419 are separated by 179 nucleotidesRv1419 and Rv1420 are separated by 63 nucleotides Rv1415: Rv1415 - Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase), at 1,590,397 to 1,591,674 Rv1415 Rv1416: Rv1416 - Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase), at 1,591,671 to 1,592,153 Rv1416 Rv1417: Rv1417 - Possible conserved membrane protein, at 1,592,150 to 1,592,614 Rv1417 Rv1418: Rv1418 - Probable lipoprotein LprH, at 1,592,639 to 1,593,325 Rv1418 Rv1419: Rv1419 - Unknown protein, at 1,593,505 to 1,593,978 Rv1419 Rv1420: Rv1420 - Probable excinuclease ABC (subunit C-nuclease) UvrC, at 1,594,042 to 1,595,982 Rv1420 Position (kb) 1592 1593 1594Strain fitness (log2 ratio) -2 -1 0 1 2at 1592.505 kb on - strand, within Rv1417at 1592.628 kb on - strandat 1592.876 kb on + strand, within Rv1418at 1592.876 kb on + strand, within Rv1418at 1592.975 kb on + strand, within Rv1418at 1592.976 kb on - strand, within Rv1418at 1592.978 kb on - strand, within Rv1418at 1592.978 kb on - strand, within Rv1418at 1593.171 kb on + strand, within Rv1418at 1593.171 kb on + strand, within Rv1418at 1593.172 kb on - strand, within Rv1418at 1593.515 kb on + strandat 1593.515 kb on + strandat 1593.516 kb on - strandat 1594.031 kb on - strandat 1594.035 kb on + strandat 1594.036 kb on - strandat 1594.036 kb on - strandat 1594.036 kb on - strandat 1594.039 kb on + strandat 1594.039 kb on + strandat 1594.039 kb on + strandat 1594.135 kb on + strandat 1594.178 kb on - strandat 1594.288 kb on + strand, within Rv1420

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Per-strain Table

Position Strand Gene LocusTag Fraction no stress control
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1,592,505 - Rv1417 0.76 -1.3
1,592,628 - +0.6
1,592,876 + Rv1418 0.34 +0.2
1,592,876 + Rv1418 0.34 -0.8
1,592,975 + Rv1418 0.49 -0.1
1,592,976 - Rv1418 0.49 -1.1
1,592,978 - Rv1418 0.49 +0.1
1,592,978 - Rv1418 0.49 -0.8
1,593,171 + Rv1418 0.77 -2.0
1,593,171 + Rv1418 0.77 -0.1
1,593,172 - Rv1418 0.78 -0.4
1,593,515 + +1.8
1,593,515 + +0.8
1,593,516 - -1.8
1,594,031 - -1.8
1,594,035 + +0.1
1,594,036 - -0.8
1,594,036 - +0.2
1,594,036 - +0.8
1,594,039 + +0.7
1,594,039 + +0.8
1,594,039 + -0.2
1,594,135 + -0.7
1,594,178 - -0.7
1,594,288 + Rv1420 0.13 -0.0

Or see this region's nucleotide sequence