Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1844c

Experiment: 7H9 with Tetrazolium violet 0.065 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1843c and Rv1844c are separated by 32 nucleotidesRv1844c and Rv1845c are separated by 29 nucleotidesRv1845c and Rv1846c are separated by 14 nucleotides Rv1843c: Rv1843c - Probable inosine-5'-monophosphate dehydrogenase GuaB1(imp dehydrogenase) (IMPDH) (IMPD), at 2,092,259 to 2,093,698 Rv1843c Rv1844c: Rv1844c - Probable 6-phosphogluconate dehydrogenase Gnd1, at 2,093,731 to 2,095,188 Rv1844c Rv1845c: Rv1845c - Possible sensor-transducer protein BlaR, at 2,095,218 to 2,096,168 Rv1845c Rv1846c: Rv1846c - Transcriptional repressor BlaI, at 2,096,183 to 2,096,599 Rv1846c Position (kb) 2093 2094 2095 2096Strain fitness (log2 ratio) -2 -1 0 1 2at 2093.082 kb on + strand, within Rv1843cat 2093.082 kb on + strand, within Rv1843cat 2093.082 kb on + strand, within Rv1843cat 2093.083 kb on - strand, within Rv1843cat 2093.083 kb on - strand, within Rv1843cat 2093.083 kb on - strand, within Rv1843cat 2093.087 kb on - strand, within Rv1843cat 2093.114 kb on + strand, within Rv1843cat 2093.226 kb on + strand, within Rv1843cat 2093.226 kb on + strand, within Rv1843cat 2093.450 kb on + strand, within Rv1843cat 2093.450 kb on + strand, within Rv1843cat 2093.451 kb on - strand, within Rv1843cat 2093.483 kb on + strand, within Rv1843cat 2093.484 kb on - strand, within Rv1843cat 2093.543 kb on - strand, within Rv1843cat 2093.652 kb on + strandat 2093.652 kb on + strandat 2093.653 kb on - strandat 2093.700 kb on + strandat 2093.700 kb on + strandat 2093.708 kb on + strandat 2093.708 kb on + strandat 2093.709 kb on - strandat 2093.718 kb on + strandat 2093.719 kb on - strandat 2093.719 kb on - strandat 2093.719 kb on - strandat 2093.719 kb on - strandat 2093.719 kb on - strandat 2093.733 kb on - strandat 2093.740 kb on + strandat 2093.741 kb on - strandat 2093.741 kb on - strandat 2093.764 kb on + strandat 2093.764 kb on + strandat 2093.764 kb on + strandat 2093.764 kb on + strandat 2093.764 kb on + strandat 2093.764 kb on + strandat 2093.765 kb on - strandat 2093.765 kb on - strandat 2093.801 kb on + strandat 2093.877 kb on - strand, within Rv1844cat 2093.877 kb on - strand, within Rv1844cat 2093.877 kb on - strand, within Rv1844cat 2093.877 kb on - strand, within Rv1844cat 2093.879 kb on + strand, within Rv1844cat 2093.879 kb on + strand, within Rv1844cat 2093.984 kb on + strand, within Rv1844cat 2094.161 kb on + strand, within Rv1844cat 2094.161 kb on + strand, within Rv1844cat 2094.161 kb on + strand, within Rv1844cat 2094.161 kb on + strand, within Rv1844cat 2094.161 kb on + strand, within Rv1844cat 2094.162 kb on - strand, within Rv1844cat 2094.182 kb on + strand, within Rv1844cat 2094.182 kb on + strand, within Rv1844cat 2094.183 kb on - strand, within Rv1844cat 2094.473 kb on + strand, within Rv1844cat 2094.473 kb on + strand, within Rv1844cat 2094.473 kb on + strand, within Rv1844cat 2094.474 kb on - strand, within Rv1844cat 2094.474 kb on - strand, within Rv1844cat 2094.474 kb on - strand, within Rv1844cat 2094.474 kb on - strand, within Rv1844cat 2094.590 kb on + strand, within Rv1844cat 2094.713 kb on + strand, within Rv1844cat 2094.714 kb on - strand, within Rv1844cat 2095.038 kb on + strand, within Rv1844cat 2095.038 kb on + strand, within Rv1844cat 2095.039 kb on - strand, within Rv1844cat 2095.088 kb on + strandat 2095.089 kb on - strandat 2095.089 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Tetrazolium violet 0.065 mM
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2,093,082 + Rv1843c 0.57 -0.5
2,093,082 + Rv1843c 0.57 +1.0
2,093,082 + Rv1843c 0.57 +0.3
2,093,083 - Rv1843c 0.57 -0.2
2,093,083 - Rv1843c 0.57 +0.1
2,093,083 - Rv1843c 0.57 -0.4
2,093,087 - Rv1843c 0.57 +2.1
2,093,114 + Rv1843c 0.59 +0.3
2,093,226 + Rv1843c 0.67 -0.7
2,093,226 + Rv1843c 0.67 +0.3
2,093,450 + Rv1843c 0.83 -0.2
2,093,450 + Rv1843c 0.83 +2.1
2,093,451 - Rv1843c 0.83 +1.4
2,093,483 + Rv1843c 0.85 -0.5
2,093,484 - Rv1843c 0.85 +1.1
2,093,543 - Rv1843c 0.89 -0.9
2,093,652 + -0.3
2,093,652 + +0.2
2,093,653 - -1.9
2,093,700 + +1.1
2,093,700 + +0.5
2,093,708 + -1.2
2,093,708 + +0.0
2,093,709 - +0.3
2,093,718 + -0.4
2,093,719 - -0.2
2,093,719 - +0.0
2,093,719 - -0.9
2,093,719 - +0.2
2,093,719 - -0.6
2,093,733 - -0.0
2,093,740 + -0.6
2,093,741 - -0.2
2,093,741 - +0.8
2,093,764 + -0.8
2,093,764 + +0.1
2,093,764 + +0.4
2,093,764 + +0.6
2,093,764 + +0.5
2,093,764 + +0.8
2,093,765 - +0.8
2,093,765 - +2.0
2,093,801 + -0.1
2,093,877 - Rv1844c 0.10 +1.8
2,093,877 - Rv1844c 0.10 -0.2
2,093,877 - Rv1844c 0.10 +0.0
2,093,877 - Rv1844c 0.10 -0.8
2,093,879 + Rv1844c 0.10 +0.3
2,093,879 + Rv1844c 0.10 -0.8
2,093,984 + Rv1844c 0.17 +0.1
2,094,161 + Rv1844c 0.29 -0.5
2,094,161 + Rv1844c 0.29 -0.2
2,094,161 + Rv1844c 0.29 -0.9
2,094,161 + Rv1844c 0.29 -0.8
2,094,161 + Rv1844c 0.29 +0.2
2,094,162 - Rv1844c 0.30 +0.9
2,094,182 + Rv1844c 0.31 -1.2
2,094,182 + Rv1844c 0.31 -0.0
2,094,183 - Rv1844c 0.31 -0.7
2,094,473 + Rv1844c 0.51 -1.4
2,094,473 + Rv1844c 0.51 -0.5
2,094,473 + Rv1844c 0.51 -0.4
2,094,474 - Rv1844c 0.51 -2.3
2,094,474 - Rv1844c 0.51 -0.4
2,094,474 - Rv1844c 0.51 +0.0
2,094,474 - Rv1844c 0.51 -0.5
2,094,590 + Rv1844c 0.59 -0.3
2,094,713 + Rv1844c 0.67 -0.3
2,094,714 - Rv1844c 0.67 -0.3
2,095,038 + Rv1844c 0.90 +0.1
2,095,038 + Rv1844c 0.90 -0.8
2,095,039 - Rv1844c 0.90 -0.0
2,095,088 + -1.1
2,095,089 - -0.5
2,095,089 - -0.2

Or see this region's nucleotide sequence