Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2008c

Experiment: 7H9 with Dibucaine 0.21 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2006 and Rv2007c are separated by 98 nucleotidesRv2007c and Rv2008c are separated by 188 nucleotidesRv2008c and Rv2009 are separated by 87 nucleotidesRv2009 and Rv2010 are separated by 0 nucleotidesRv2010 and Rv2011c are separated by 182 nucleotides Rv2006: Rv2006 - Probable trehalose-6-phosphate phosphatase OtsB1 (trehalose-phosphatase) (TPP), at 2,252,002 to 2,255,985 Rv2006 Rv2007c: Rv2007c - Ferredoxin FdxA, at 2,256,084 to 2,256,428 Rv2007c Rv2008c: Rv2008c - Conserved hypothetical protein, at 2,256,617 to 2,257,942 Rv2008c Rv2009: Rv2009 - Antitoxin VapB15, at 2,258,030 to 2,258,272 Rv2009 Rv2010: Rv2010 - Toxin VapC15, at 2,258,273 to 2,258,671 Rv2010 Rv2011c: Rv2011c - Conserved hypothetical protein, probable transcription repressor., at 2,258,854 to 2,259,285 Rv2011c Position (kb) 2256 2257 2258Strain fitness (log2 ratio) -2 -1 0 1 2 3 4at 2255.636 kb on - strandat 2255.636 kb on - strandat 2256.246 kb on + strand, within Rv2007cat 2256.262 kb on + strand, within Rv2007cat 2256.350 kb on - strand, within Rv2007cat 2256.441 kb on - strandat 2256.606 kb on - strandat 2256.794 kb on - strand, within Rv2008cat 2256.882 kb on + strand, within Rv2008cat 2256.882 kb on + strand, within Rv2008cat 2257.282 kb on - strand, within Rv2008cat 2257.337 kb on + strand, within Rv2008cat 2257.481 kb on - strand, within Rv2008cat 2257.590 kb on - strand, within Rv2008cat 2257.739 kb on + strand, within Rv2008cat 2257.865 kb on + strandat 2257.866 kb on - strandat 2258.008 kb on + strandat 2258.008 kb on + strandat 2258.008 kb on + strandat 2258.008 kb on + strandat 2258.008 kb on + strandat 2258.009 kb on - strandat 2258.102 kb on + strand, within Rv2009at 2258.103 kb on - strand, within Rv2009at 2258.270 kb on + strandat 2258.271 kb on - strandat 2258.271 kb on - strandat 2258.303 kb on + strandat 2258.544 kb on + strand, within Rv2010at 2258.545 kb on - strand, within Rv2010at 2258.545 kb on - strand, within Rv2010at 2258.738 kb on - strandat 2258.747 kb on + strandat 2258.790 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Dibucaine 0.21 mM
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2,255,636 - -0.6
2,255,636 - -0.2
2,256,246 + Rv2007c 0.47 -1.1
2,256,262 + Rv2007c 0.52 -0.3
2,256,350 - Rv2007c 0.77 +0.1
2,256,441 - -0.1
2,256,606 - -0.5
2,256,794 - Rv2008c 0.13 +2.8
2,256,882 + Rv2008c 0.20 +1.4
2,256,882 + Rv2008c 0.20 +0.4
2,257,282 - Rv2008c 0.50 +0.7
2,257,337 + Rv2008c 0.54 -0.4
2,257,481 - Rv2008c 0.65 -0.2
2,257,590 - Rv2008c 0.73 -0.6
2,257,739 + Rv2008c 0.85 -0.2
2,257,865 + -1.4
2,257,866 - -2.3
2,258,008 + -0.9
2,258,008 + -0.2
2,258,008 + -0.0
2,258,008 + +1.8
2,258,008 + -0.2
2,258,009 - -0.4
2,258,102 + Rv2009 0.30 -1.4
2,258,103 - Rv2009 0.30 -0.2
2,258,270 + -0.3
2,258,271 - +0.1
2,258,271 - +4.1
2,258,303 + +0.1
2,258,544 + Rv2010 0.68 +0.9
2,258,545 - Rv2010 0.68 +0.3
2,258,545 - Rv2010 0.68 +0.0
2,258,738 - -0.6
2,258,747 + +0.9
2,258,790 - -0.4

Or see this region's nucleotide sequence