Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2237A

Experiment: 7H9 with Dibucaine 0.21 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2236c and Rv2237 are separated by 113 nucleotidesRv2237 and Rv2237A are separated by 94 nucleotidesRv2237A and GFF2321 are separated by 10 nucleotidesGFF2321 and Rv2238c are separated by 45 nucleotidesRv2238c and Rv2239c overlap by 1 nucleotides Rv2236c: Rv2236c - Probable cobalamin biosynthesis transmembrane protein CobD, at 2,508,434 to 2,509,375 Rv2236c Rv2237: Rv2237 - Conserved protein, at 2,509,489 to 2,510,256 Rv2237 Rv2237A: Rv2237A - Conserved protein, at 2,510,351 to 2,510,587 Rv2237A GFF2321 - tRNA-Val, at 2,510,598 to 2,510,669 GFF2321 Rv2238c: Rv2238c - Probable peroxiredoxin AhpE, at 2,510,715 to 2,511,176 Rv2238c Rv2239c: Rv2239c - Conserved hypothetical protein, at 2,511,176 to 2,511,652 Rv2239c Position (kb) 2510 2511Strain fitness (log2 ratio) -1 0 1 2 3 4 5at 2509.400 kb on + strandat 2509.401 kb on - strandat 2509.410 kb on + strandat 2509.414 kb on + strandat 2509.424 kb on + strandat 2509.433 kb on + strandat 2509.582 kb on + strand, within Rv2237at 2509.582 kb on + strand, within Rv2237at 2509.583 kb on - strand, within Rv2237at 2509.621 kb on + strand, within Rv2237at 2509.622 kb on - strand, within Rv2237at 2509.622 kb on - strand, within Rv2237at 2509.729 kb on + strand, within Rv2237at 2509.730 kb on - strand, within Rv2237at 2509.732 kb on - strand, within Rv2237at 2509.777 kb on + strand, within Rv2237at 2509.783 kb on + strand, within Rv2237at 2510.151 kb on - strand, within Rv2237at 2510.207 kb on - strandat 2510.437 kb on - strand, within Rv2237Aat 2510.437 kb on - strand, within Rv2237Aat 2510.592 kb on - strandat 2510.724 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Dibucaine 0.21 mM
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2,509,400 + -0.4
2,509,401 - -0.8
2,509,410 + -1.4
2,509,414 + +0.2
2,509,424 + +1.8
2,509,433 + -0.3
2,509,582 + Rv2237 0.12 -0.2
2,509,582 + Rv2237 0.12 -0.6
2,509,583 - Rv2237 0.12 +0.6
2,509,621 + Rv2237 0.17 +0.1
2,509,622 - Rv2237 0.17 -0.3
2,509,622 - Rv2237 0.17 +0.1
2,509,729 + Rv2237 0.31 -0.7
2,509,730 - Rv2237 0.31 -0.2
2,509,732 - Rv2237 0.32 -1.7
2,509,777 + Rv2237 0.38 -0.3
2,509,783 + Rv2237 0.38 -0.1
2,510,151 - Rv2237 0.86 +4.8
2,510,207 - +0.6
2,510,437 - Rv2237A 0.36 -1.3
2,510,437 - Rv2237A 0.36 -1.4
2,510,592 - -0.4
2,510,724 - -0.8

Or see this region's nucleotide sequence