Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3905c

Experiment: 7H9 with Tetracycline 0.0058 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3903c and Rv3904c are separated by 4 nucleotidesRv3904c and Rv3905c are separated by 10 nucleotidesRv3905c and Rv3906c are separated by 65 nucleotidesRv3906c and Rv3907c are separated by 24 nucleotides Rv3903c: Rv3903c - Hypothetical alanine and proline rich protein, at 4,387,892 to 4,390,432 Rv3903c Rv3904c: Rv3904c - Putative ESAT-6 like protein EsxE (hypothetical alanine rich protein) (ESAT-6 like protein 12), at 4,390,437 to 4,390,709 Rv3904c Rv3905c: Rv3905c - Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13), at 4,390,720 to 4,391,031 Rv3905c Rv3906c: Rv3906c - Conserved hypothetical protein, at 4,391,097 to 4,391,606 Rv3906c Rv3907c: Rv3907c - Probable poly(A) polymerase PcnA (polynucleotide adenylyltransferase) (NTP polymerase) (RNA adenylating enzyme) (poly(A) polymerase), at 4,391,631 to 4,393,073 Rv3907c Position (kb) 4390 4391 4392Strain fitness (log2 ratio) -2 -1 0 1at 4389.777 kb on + strand, within Rv3903cat 4389.785 kb on + strand, within Rv3903cat 4389.786 kb on - strand, within Rv3903cat 4389.838 kb on - strand, within Rv3903cat 4389.895 kb on + strand, within Rv3903cat 4389.980 kb on + strand, within Rv3903cat 4389.981 kb on - strand, within Rv3903cat 4390.020 kb on + strand, within Rv3903cat 4390.021 kb on - strand, within Rv3903cat 4390.021 kb on - strand, within Rv3903cat 4390.170 kb on + strand, within Rv3903cat 4390.171 kb on - strand, within Rv3903cat 4390.397 kb on - strandat 4390.449 kb on - strandat 4390.449 kb on - strandat 4390.477 kb on + strand, within Rv3904cat 4390.477 kb on + strand, within Rv3904cat 4390.477 kb on + strand, within Rv3904cat 4390.477 kb on + strand, within Rv3904cat 4390.478 kb on - strand, within Rv3904cat 4390.478 kb on - strand, within Rv3904cat 4390.478 kb on - strand, within Rv3904cat 4390.478 kb on - strand, within Rv3904cat 4390.616 kb on + strand, within Rv3904cat 4390.852 kb on + strand, within Rv3905cat 4390.853 kb on - strand, within Rv3905cat 4390.871 kb on + strand, within Rv3905cat 4390.872 kb on - strand, within Rv3905cat 4391.042 kb on + strandat 4391.043 kb on - strandat 4391.043 kb on - strandat 4391.043 kb on - strandat 4391.098 kb on + strandat 4391.098 kb on + strandat 4391.099 kb on - strandat 4391.151 kb on + strand, within Rv3906cat 4391.151 kb on + strand, within Rv3906cat 4391.151 kb on + strand, within Rv3906cat 4391.152 kb on - strand, within Rv3906cat 4391.186 kb on - strand, within Rv3906cat 4391.253 kb on + strand, within Rv3906cat 4391.329 kb on + strand, within Rv3906cat 4391.330 kb on - strand, within Rv3906cat 4391.395 kb on + strand, within Rv3906cat 4391.396 kb on - strand, within Rv3906cat 4391.599 kb on + strandat 4391.600 kb on - strandat 4391.600 kb on - strandat 4391.632 kb on + strandat 4391.633 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Tetracycline 0.0058 mM
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4,389,777 + Rv3903c 0.74 -0.4
4,389,785 + Rv3903c 0.74 +0.9
4,389,786 - Rv3903c 0.75 +1.6
4,389,838 - Rv3903c 0.77 +1.7
4,389,895 + Rv3903c 0.79 -1.1
4,389,980 + Rv3903c 0.82 -0.6
4,389,981 - Rv3903c 0.82 +0.4
4,390,020 + Rv3903c 0.84 -0.2
4,390,021 - Rv3903c 0.84 -0.3
4,390,021 - Rv3903c 0.84 -0.1
4,390,170 + Rv3903c 0.90 -0.2
4,390,171 - Rv3903c 0.90 +0.1
4,390,397 - -0.2
4,390,449 - -0.2
4,390,449 - -0.9
4,390,477 + Rv3904c 0.15 +0.1
4,390,477 + Rv3904c 0.15 -0.5
4,390,477 + Rv3904c 0.15 -0.2
4,390,477 + Rv3904c 0.15 +1.7
4,390,478 - Rv3904c 0.15 +0.6
4,390,478 - Rv3904c 0.15 -0.6
4,390,478 - Rv3904c 0.15 -0.1
4,390,478 - Rv3904c 0.15 -1.1
4,390,616 + Rv3904c 0.66 -0.4
4,390,852 + Rv3905c 0.42 +0.5
4,390,853 - Rv3905c 0.43 -1.1
4,390,871 + Rv3905c 0.48 -0.7
4,390,872 - Rv3905c 0.49 -0.7
4,391,042 + -2.4
4,391,043 - +1.7
4,391,043 - -0.5
4,391,043 - -0.3
4,391,098 + -0.6
4,391,098 + -0.3
4,391,099 - -1.6
4,391,151 + Rv3906c 0.11 -0.5
4,391,151 + Rv3906c 0.11 -0.1
4,391,151 + Rv3906c 0.11 -0.5
4,391,152 - Rv3906c 0.11 +1.7
4,391,186 - Rv3906c 0.17 +1.1
4,391,253 + Rv3906c 0.31 -0.1
4,391,329 + Rv3906c 0.45 +0.1
4,391,330 - Rv3906c 0.46 -0.5
4,391,395 + Rv3906c 0.58 -0.8
4,391,396 - Rv3906c 0.59 -0.2
4,391,599 + +1.7
4,391,600 - -0.5
4,391,600 - +0.2
4,391,632 + -0.5
4,391,633 - +0.8

Or see this region's nucleotide sequence