Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2779c

Experiment: 7H9 with Tetracycline 0.0058 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2777c and Rv2778c are separated by 157 nucleotidesRv2778c and Rv2779c are separated by 31 nucleotidesRv2779c and Rv2780 are separated by 65 nucleotides Rv2777c: Rv2777c - Conserved hypothetical protein, at 3,084,485 to 3,085,555 Rv2777c Rv2778c: Rv2778c - Conserved protein, at 3,085,713 to 3,086,183 Rv2778c Rv2779c: Rv2779c - Possible transcriptional regulatory protein (probably Lrp/AsnC-family), at 3,086,215 to 3,086,754 Rv2779c Rv2780: Rv2780 - Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43), at 3,086,820 to 3,087,935 Rv2780 Position (kb) 3086 3087Strain fitness (log2 ratio) -2 -1 0 1 2 3at 3085.232 kb on - strand, within Rv2777cat 3085.232 kb on - strand, within Rv2777cat 3085.278 kb on + strand, within Rv2777cat 3085.278 kb on + strand, within Rv2777cat 3085.278 kb on + strand, within Rv2777cat 3085.278 kb on + strand, within Rv2777cat 3085.279 kb on - strand, within Rv2777cat 3085.279 kb on - strand, within Rv2777cat 3085.441 kb on - strand, within Rv2777cat 3085.464 kb on + strandat 3085.485 kb on + strandat 3085.485 kb on + strandat 3085.485 kb on + strandat 3085.488 kb on - strandat 3085.488 kb on - strandat 3085.488 kb on - strandat 3085.488 kb on - strandat 3085.644 kb on - strandat 3085.891 kb on + strand, within Rv2778cat 3085.892 kb on - strand, within Rv2778cat 3085.913 kb on + strand, within Rv2778cat 3085.914 kb on - strand, within Rv2778cat 3085.914 kb on - strand, within Rv2778cat 3085.926 kb on + strand, within Rv2778cat 3085.927 kb on - strand, within Rv2778cat 3085.927 kb on - strand, within Rv2778cat 3085.927 kb on - strand, within Rv2778cat 3086.118 kb on + strand, within Rv2778cat 3086.118 kb on + strand, within Rv2778cat 3086.195 kb on - strandat 3086.217 kb on - strandat 3086.217 kb on - strandat 3086.266 kb on - strandat 3086.376 kb on - strand, within Rv2779cat 3086.376 kb on - strand, within Rv2779cat 3086.376 kb on - strand, within Rv2779cat 3086.511 kb on - strand, within Rv2779cat 3086.593 kb on + strand, within Rv2779cat 3086.750 kb on - strandat 3086.798 kb on + strandat 3086.897 kb on - strandat 3087.029 kb on - strand, within Rv2780at 3087.168 kb on + strand, within Rv2780at 3087.200 kb on - strand, within Rv2780at 3087.258 kb on + strand, within Rv2780at 3087.258 kb on + strand, within Rv2780at 3087.620 kb on - strand, within Rv2780at 3087.667 kb on - strand, within Rv2780at 3087.751 kb on - strand, within Rv2780

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Tetracycline 0.0058 mM
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3,085,232 - Rv2777c 0.70 -0.1
3,085,232 - Rv2777c 0.70 -0.1
3,085,278 + Rv2777c 0.74 -0.1
3,085,278 + Rv2777c 0.74 -0.1
3,085,278 + Rv2777c 0.74 +0.5
3,085,278 + Rv2777c 0.74 -0.3
3,085,279 - Rv2777c 0.74 -1.4
3,085,279 - Rv2777c 0.74 +0.4
3,085,441 - Rv2777c 0.89 -0.6
3,085,464 + +2.3
3,085,485 + +0.2
3,085,485 + -0.8
3,085,485 + -0.4
3,085,488 - -0.8
3,085,488 - +0.0
3,085,488 - -0.5
3,085,488 - +0.9
3,085,644 - -0.1
3,085,891 + Rv2778c 0.38 -0.4
3,085,892 - Rv2778c 0.38 +0.0
3,085,913 + Rv2778c 0.42 -1.1
3,085,914 - Rv2778c 0.43 -1.5
3,085,914 - Rv2778c 0.43 -0.2
3,085,926 + Rv2778c 0.45 +1.7
3,085,927 - Rv2778c 0.45 -0.3
3,085,927 - Rv2778c 0.45 +3.0
3,085,927 - Rv2778c 0.45 -1.1
3,086,118 + Rv2778c 0.86 +1.0
3,086,118 + Rv2778c 0.86 +0.1
3,086,195 - -0.7
3,086,217 - +0.5
3,086,217 - -0.4
3,086,266 - +1.2
3,086,376 - Rv2779c 0.30 -0.7
3,086,376 - Rv2779c 0.30 -0.9
3,086,376 - Rv2779c 0.30 -0.5
3,086,511 - Rv2779c 0.55 -2.1
3,086,593 + Rv2779c 0.70 -0.4
3,086,750 - -0.1
3,086,798 + +1.0
3,086,897 - +1.0
3,087,029 - Rv2780 0.19 -0.4
3,087,168 + Rv2780 0.31 +0.3
3,087,200 - Rv2780 0.34 -0.4
3,087,258 + Rv2780 0.39 -0.3
3,087,258 + Rv2780 0.39 -0.4
3,087,620 - Rv2780 0.72 -0.6
3,087,667 - Rv2780 0.76 +0.1
3,087,751 - Rv2780 0.83 -0.2

Or see this region's nucleotide sequence