Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1243c

Experiment: 7H9 with Tetracycline 0.0058 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1240 and Rv1241 are separated by 75 nucleotidesRv1241 and Rv1242 overlap by 4 nucleotidesRv1242 and Rv1243c are separated by 22 nucleotidesRv1243c and Rv1244 are separated by 179 nucleotides Rv1240: Rv1240 - Probable malate dehydrogenase Mdh, at 1,383,213 to 1,384,202 Rv1240 Rv1241: Rv1241 - Possible antitoxin VapB33, at 1,384,278 to 1,384,538 Rv1241 Rv1242: Rv1242 - Possible toxin VapC33. Contains PIN domain., at 1,384,535 to 1,384,966 Rv1242 Rv1243c: Rv1243c - PE-PGRS family protein PE_PGRS23, at 1,384,989 to 1,386,677 Rv1243c Rv1244: Rv1244 - Probable lipoprotein LpqZ, at 1,386,857 to 1,387,717 Rv1244 Position (kb) 1384 1385 1386 1387Strain fitness (log2 ratio) -3 -2 -1 0 1at 1384.565 kb on + strandat 1384.565 kb on + strandat 1384.740 kb on - strand, within Rv1242at 1384.776 kb on + strand, within Rv1242at 1384.777 kb on - strand, within Rv1242at 1384.964 kb on + strandat 1385.025 kb on - strandat 1385.507 kb on + strand, within Rv1243cat 1385.593 kb on - strand, within Rv1243cat 1385.833 kb on - strand, within Rv1243cat 1386.027 kb on + strand, within Rv1243cat 1386.120 kb on + strand, within Rv1243cat 1386.239 kb on + strand, within Rv1243cat 1386.240 kb on - strand, within Rv1243cat 1386.268 kb on + strand, within Rv1243cat 1386.268 kb on + strand, within Rv1243cat 1386.418 kb on + strand, within Rv1243cat 1386.493 kb on + strand, within Rv1243cat 1386.493 kb on + strand, within Rv1243cat 1386.537 kb on + strandat 1386.537 kb on + strandat 1386.537 kb on + strandat 1386.537 kb on + strandat 1386.537 kb on + strandat 1386.594 kb on - strandat 1386.670 kb on + strandat 1386.670 kb on + strandat 1386.670 kb on + strandat 1386.670 kb on + strandat 1386.670 kb on + strandat 1386.671 kb on - strandat 1386.837 kb on - strandat 1387.007 kb on + strand, within Rv1244at 1387.008 kb on - strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.170 kb on + strand, within Rv1244at 1387.171 kb on - strand, within Rv1244at 1387.172 kb on + strand, within Rv1244

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Tetracycline 0.0058 mM
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1,384,565 + +0.2
1,384,565 + -0.3
1,384,740 - Rv1242 0.47 -1.3
1,384,776 + Rv1242 0.56 -0.7
1,384,777 - Rv1242 0.56 +0.2
1,384,964 + -0.1
1,385,025 - -0.0
1,385,507 + Rv1243c 0.31 -0.9
1,385,593 - Rv1243c 0.36 -0.9
1,385,833 - Rv1243c 0.50 -1.0
1,386,027 + Rv1243c 0.61 -0.6
1,386,120 + Rv1243c 0.67 -0.4
1,386,239 + Rv1243c 0.74 -0.0
1,386,240 - Rv1243c 0.74 -0.4
1,386,268 + Rv1243c 0.76 -1.4
1,386,268 + Rv1243c 0.76 -1.5
1,386,418 + Rv1243c 0.85 -1.6
1,386,493 + Rv1243c 0.89 +0.7
1,386,493 + Rv1243c 0.89 -1.1
1,386,537 + +0.4
1,386,537 + +0.2
1,386,537 + -1.0
1,386,537 + -2.8
1,386,537 + -0.3
1,386,594 - -0.4
1,386,670 + +0.1
1,386,670 + -0.5
1,386,670 + -0.2
1,386,670 + +1.0
1,386,670 + -0.8
1,386,671 - +0.1
1,386,837 - -0.1
1,387,007 + Rv1244 0.17 -2.3
1,387,008 - Rv1244 0.18 -1.0
1,387,170 + Rv1244 0.36 -1.5
1,387,170 + Rv1244 0.36 -0.5
1,387,170 + Rv1244 0.36 +1.7
1,387,170 + Rv1244 0.36 +0.7
1,387,170 + Rv1244 0.36 -0.3
1,387,171 - Rv1244 0.36 -0.4
1,387,172 + Rv1244 0.37 -1.3

Or see this region's nucleotide sequence