Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1111c

Experiment: 7H9 with Tetracycline 0.0058 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1110 and Rv1111c are separated by 16 nucleotidesRv1111c and Rv1112 are separated by 62 nucleotides Rv1110: Rv1110 - Probable LYTB-related protein LytB2, at 1,236,185 to 1,237,192 Rv1110 Rv1111c: Rv1111c - Conserved hypothetical protein, at 1,237,209 to 1,238,192 Rv1111c Rv1112: Rv1112 - Probable GTP binding protein, at 1,238,255 to 1,239,328 Rv1112 Position (kb) 1237 1238 1239Strain fitness (log2 ratio) -2 -1 0 1 2at 1237.208 kb on + strandat 1237.211 kb on - strandat 1237.211 kb on - strandat 1237.219 kb on + strandat 1237.219 kb on + strandat 1237.294 kb on + strandat 1237.295 kb on - strandat 1237.295 kb on - strandat 1237.295 kb on - strandat 1237.408 kb on + strand, within Rv1111cat 1237.421 kb on - strand, within Rv1111cat 1237.459 kb on + strand, within Rv1111cat 1237.775 kb on - strand, within Rv1111cat 1237.775 kb on - strand, within Rv1111cat 1238.349 kb on - strandat 1238.853 kb on - strand, within Rv1112at 1238.853 kb on - strand, within Rv1112at 1238.853 kb on - strand, within Rv1112

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Tetracycline 0.0058 mM
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1,237,208 + -0.6
1,237,211 - -0.6
1,237,211 - +0.5
1,237,219 + +0.7
1,237,219 + +0.3
1,237,294 + +0.1
1,237,295 - -0.1
1,237,295 - -0.6
1,237,295 - +2.3
1,237,408 + Rv1111c 0.20 -1.3
1,237,421 - Rv1111c 0.22 -1.2
1,237,459 + Rv1111c 0.25 -0.1
1,237,775 - Rv1111c 0.58 -0.6
1,237,775 - Rv1111c 0.58 -1.6
1,238,349 - -0.6
1,238,853 - Rv1112 0.56 -2.2
1,238,853 - Rv1112 0.56 +0.3
1,238,853 - Rv1112 0.56 -1.1

Or see this region's nucleotide sequence