Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0381c

Experiment: 7H9 with Tetracycline 0.0058 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0379 and Rv0380c are separated by 75 nucleotidesRv0380c and Rv0381c are separated by 95 nucleotidesRv0381c and Rv0382c are separated by 17 nucleotidesRv0382c and Rv0383c are separated by 80 nucleotides Rv0379: Rv0379 - Possible protein transport protein SecE2, at 455,977 to 456,192 Rv0379 Rv0380c: Rv0380c - Possible RNA methyltransferase (RNA methylase), at 456,268 to 456,819 Rv0380c Rv0381c: Rv0381c - Hypothetical protein, at 456,915 to 457,823 Rv0381c Rv0382c: Rv0382c - Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase), at 457,841 to 458,380 Rv0382c Rv0383c: Rv0383c - Possible conserved secreted protein, at 458,461 to 459,315 Rv0383c Position (kb) 456 457 458Strain fitness (log2 ratio) -1 0 1at 455.961 kb on + strandat 455.961 kb on + strandat 455.963 kb on + strandat 455.963 kb on + strandat 455.970 kb on + strandat 455.986 kb on + strandat 455.987 kb on - strandat 455.987 kb on - strandat 455.987 kb on - strandat 456.139 kb on + strand, within Rv0379at 456.139 kb on + strand, within Rv0379at 456.190 kb on + strandat 456.269 kb on + strandat 456.270 kb on - strandat 456.412 kb on - strand, within Rv0380cat 456.827 kb on + strandat 456.895 kb on - strandat 456.968 kb on - strandat 456.999 kb on - strandat 456.999 kb on - strandat 457.013 kb on + strand, within Rv0381cat 457.066 kb on + strand, within Rv0381cat 457.066 kb on + strand, within Rv0381cat 457.066 kb on + strand, within Rv0381cat 457.067 kb on - strand, within Rv0381cat 457.202 kb on - strand, within Rv0381cat 457.202 kb on - strand, within Rv0381cat 457.244 kb on + strand, within Rv0381cat 457.244 kb on + strand, within Rv0381cat 457.354 kb on + strand, within Rv0381cat 457.368 kb on - strand, within Rv0381cat 457.399 kb on + strand, within Rv0381cat 457.645 kb on + strand, within Rv0381cat 457.645 kb on + strand, within Rv0381cat 457.645 kb on + strand, within Rv0381cat 457.646 kb on - strand, within Rv0381cat 458.624 kb on - strand, within Rv0383c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Tetracycline 0.0058 mM
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455,961 + -0.3
455,961 + -1.6
455,963 + +0.3
455,963 + -0.7
455,970 + -0.1
455,986 + -0.2
455,987 - +0.0
455,987 - +0.2
455,987 - -0.4
456,139 + Rv0379 0.75 -0.4
456,139 + Rv0379 0.75 +0.4
456,190 + -0.4
456,269 + -0.2
456,270 - -0.0
456,412 - Rv0380c 0.26 -1.1
456,827 + -0.6
456,895 - -0.5
456,968 - -0.5
456,999 - +0.2
456,999 - -0.5
457,013 + Rv0381c 0.11 -0.2
457,066 + Rv0381c 0.17 +0.4
457,066 + Rv0381c 0.17 +0.1
457,066 + Rv0381c 0.17 -1.2
457,067 - Rv0381c 0.17 +0.3
457,202 - Rv0381c 0.32 -0.3
457,202 - Rv0381c 0.32 -0.5
457,244 + Rv0381c 0.36 -0.9
457,244 + Rv0381c 0.36 -0.5
457,354 + Rv0381c 0.48 +0.4
457,368 - Rv0381c 0.50 -0.6
457,399 + Rv0381c 0.53 -0.0
457,645 + Rv0381c 0.80 +0.3
457,645 + Rv0381c 0.80 -0.6
457,645 + Rv0381c 0.80 -0.6
457,646 - Rv0381c 0.80 -0.4
458,624 - Rv0383c 0.19 -0.4

Or see this region's nucleotide sequence