Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2047c

Experiment: 7H9 with 8-hydroxy-nitroquinoline 0.03 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2045c and Rv2046 are separated by 48 nucleotidesRv2046 and Rv2047c are separated by 36 nucleotidesRv2047c and Rv2048c are separated by 4 nucleotides Rv2045c: Rv2045c - Carboxylesterase LipT, at 2,289,685 to 2,291,220 Rv2045c Rv2046: Rv2046 - Probable lipoprotein LppI, at 2,291,269 to 2,291,925 Rv2046 Rv2047c: Rv2047c - Conserved hypothetical protein, at 2,291,962 to 2,294,526 Rv2047c Rv2048c: Rv2048c - Polyketide synthase Pks12, at 2,294,531 to 2,306,986 Rv2048c Position (kb) 2291 2292 2293 2294 2295Strain fitness (log2 ratio) -4 -3 -2 -1 0 1at 2291.100 kb on - strandat 2291.190 kb on + strandat 2291.191 kb on - strandat 2291.340 kb on - strand, within Rv2046at 2291.557 kb on - strand, within Rv2046at 2291.726 kb on - strand, within Rv2046at 2291.818 kb on + strand, within Rv2046at 2291.957 kb on + strandat 2291.957 kb on + strandat 2291.957 kb on + strandat 2291.958 kb on - strandat 2292.082 kb on - strandat 2292.082 kb on - strandat 2292.183 kb on - strandat 2292.319 kb on + strand, within Rv2047cat 2292.743 kb on + strand, within Rv2047cat 2292.841 kb on + strand, within Rv2047cat 2292.842 kb on - strand, within Rv2047cat 2293.163 kb on + strand, within Rv2047cat 2293.234 kb on + strand, within Rv2047cat 2293.243 kb on + strand, within Rv2047cat 2293.243 kb on + strand, within Rv2047cat 2293.406 kb on + strand, within Rv2047cat 2293.897 kb on + strand, within Rv2047cat 2293.914 kb on + strand, within Rv2047cat 2293.983 kb on + strand, within Rv2047cat 2294.078 kb on + strand, within Rv2047cat 2294.078 kb on + strand, within Rv2047cat 2294.724 kb on - strandat 2294.793 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with 8-hydroxy-nitroquinoline 0.03 mM
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2,291,100 - +1.7
2,291,190 + +0.1
2,291,191 - -0.4
2,291,340 - Rv2046 0.11 +0.4
2,291,557 - Rv2046 0.44 +0.0
2,291,726 - Rv2046 0.70 -1.1
2,291,818 + Rv2046 0.84 +0.9
2,291,957 + -0.3
2,291,957 + -0.4
2,291,957 + +0.0
2,291,958 - -0.2
2,292,082 - -0.1
2,292,082 - -3.3
2,292,183 - -3.1
2,292,319 + Rv2047c 0.14 -1.8
2,292,743 + Rv2047c 0.30 -2.7
2,292,841 + Rv2047c 0.34 -2.3
2,292,842 - Rv2047c 0.34 -0.9
2,293,163 + Rv2047c 0.47 -0.3
2,293,234 + Rv2047c 0.50 -1.9
2,293,243 + Rv2047c 0.50 -4.1
2,293,243 + Rv2047c 0.50 -2.3
2,293,406 + Rv2047c 0.56 -2.8
2,293,897 + Rv2047c 0.75 -2.7
2,293,914 + Rv2047c 0.76 -1.6
2,293,983 + Rv2047c 0.79 -2.6
2,294,078 + Rv2047c 0.82 -1.8
2,294,078 + Rv2047c 0.82 -2.9
2,294,724 - -1.3
2,294,793 + -2.2

Or see this region's nucleotide sequence