Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0450c

Experiment: 7H9 with 8-hydroxy-nitroquinoline 0.03 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0449c and Rv0450c are separated by 39 nucleotidesRv0450c and Rv0451c overlap by 4 nucleotidesRv0451c and Rv0452 are separated by 231 nucleotides Rv0449c: Rv0449c - Conserved hypothetical protein, at 537,229 to 538,548 Rv0449c Rv0450c: Rv0450c - Probable conserved transmembrane transport protein MmpL4, at 538,588 to 541,491 Rv0450c Rv0451c: Rv0451c - Probable conserved membrane protein MmpS4, at 541,488 to 541,910 Rv0451c Rv0452: Rv0452 - Possible transcriptional regulatory protein, at 542,142 to 542,852 Rv0452 Position (kb) 538 539 540 541 542Strain fitness (log2 ratio) -2 -1 0 1 2at 537.866 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.866 kb on + strand, within Rv0449cat 537.867 kb on - strand, within Rv0449cat 537.953 kb on + strand, within Rv0449cat 537.954 kb on - strand, within Rv0449cat 538.037 kb on + strand, within Rv0449cat 538.038 kb on - strand, within Rv0449cat 538.170 kb on - strand, within Rv0449cat 538.170 kb on - strand, within Rv0449cat 538.230 kb on - strand, within Rv0449cat 538.230 kb on - strand, within Rv0449cat 538.325 kb on + strand, within Rv0449cat 538.326 kb on - strand, within Rv0449cat 538.407 kb on - strand, within Rv0449cat 538.407 kb on - strand, within Rv0449cat 538.448 kb on + strandat 538.449 kb on - strandat 538.449 kb on - strandat 538.481 kb on + strandat 538.481 kb on + strandat 538.481 kb on + strandat 538.555 kb on + strandat 538.712 kb on - strandat 538.921 kb on + strand, within Rv0450cat 538.922 kb on - strand, within Rv0450cat 539.475 kb on + strand, within Rv0450cat 539.859 kb on + strand, within Rv0450cat 539.862 kb on + strand, within Rv0450cat 539.887 kb on - strand, within Rv0450cat 540.244 kb on + strand, within Rv0450cat 540.264 kb on - strand, within Rv0450cat 540.264 kb on - strand, within Rv0450cat 540.396 kb on + strand, within Rv0450cat 540.430 kb on + strand, within Rv0450cat 540.430 kb on + strand, within Rv0450cat 540.431 kb on - strand, within Rv0450cat 540.472 kb on + strand, within Rv0450cat 540.473 kb on - strand, within Rv0450cat 540.513 kb on - strand, within Rv0450cat 540.597 kb on - strand, within Rv0450cat 540.605 kb on + strand, within Rv0450cat 540.605 kb on + strand, within Rv0450cat 540.606 kb on - strand, within Rv0450cat 540.609 kb on - strand, within Rv0450cat 540.674 kb on + strand, within Rv0450cat 540.675 kb on - strand, within Rv0450cat 540.748 kb on - strand, within Rv0450cat 540.900 kb on + strand, within Rv0450cat 541.510 kb on + strandat 541.644 kb on - strand, within Rv0451cat 541.801 kb on + strand, within Rv0451cat 541.905 kb on + strandat 541.906 kb on - strandat 541.906 kb on - strandat 541.906 kb on - strandat 541.995 kb on + strandat 541.995 kb on + strandat 542.009 kb on + strandat 542.038 kb on - strandat 542.038 kb on - strandat 542.059 kb on + strandat 542.059 kb on + strandat 542.060 kb on - strandat 542.079 kb on - strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.107 kb on + strandat 542.108 kb on - strandat 542.399 kb on - strand, within Rv0452

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with 8-hydroxy-nitroquinoline 0.03 mM
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537,866 + Rv0449c 0.48 +0.3
537,866 + Rv0449c 0.48 -0.0
537,866 + Rv0449c 0.48 -2.0
537,866 + Rv0449c 0.48 +0.0
537,866 + Rv0449c 0.48 +0.7
537,867 - Rv0449c 0.48 -1.3
537,953 + Rv0449c 0.55 -0.3
537,954 - Rv0449c 0.55 -0.6
538,037 + Rv0449c 0.61 +0.8
538,038 - Rv0449c 0.61 -1.3
538,170 - Rv0449c 0.71 -0.2
538,170 - Rv0449c 0.71 +0.6
538,230 - Rv0449c 0.76 -0.6
538,230 - Rv0449c 0.76 +0.1
538,325 + Rv0449c 0.83 +0.2
538,326 - Rv0449c 0.83 -0.9
538,407 - Rv0449c 0.89 +1.7
538,407 - Rv0449c 0.89 -0.5
538,448 + +0.3
538,449 - +0.3
538,449 - -0.2
538,481 + -1.2
538,481 + +0.4
538,481 + -0.2
538,555 + -0.0
538,712 - -2.2
538,921 + Rv0450c 0.11 +2.7
538,922 - Rv0450c 0.12 -1.3
539,475 + Rv0450c 0.31 -0.3
539,859 + Rv0450c 0.44 -1.1
539,862 + Rv0450c 0.44 -0.9
539,887 - Rv0450c 0.45 -1.4
540,244 + Rv0450c 0.57 -1.2
540,264 - Rv0450c 0.58 -0.2
540,264 - Rv0450c 0.58 -0.7
540,396 + Rv0450c 0.62 +0.1
540,430 + Rv0450c 0.63 +0.1
540,430 + Rv0450c 0.63 -0.6
540,431 - Rv0450c 0.63 -0.4
540,472 + Rv0450c 0.65 -1.5
540,473 - Rv0450c 0.65 -1.1
540,513 - Rv0450c 0.66 +2.2
540,597 - Rv0450c 0.69 -0.3
540,605 + Rv0450c 0.69 -0.9
540,605 + Rv0450c 0.69 -1.2
540,606 - Rv0450c 0.69 -1.7
540,609 - Rv0450c 0.70 -1.0
540,674 + Rv0450c 0.72 -0.9
540,675 - Rv0450c 0.72 -0.5
540,748 - Rv0450c 0.74 +0.1
540,900 + Rv0450c 0.80 -1.2
541,510 + -0.7
541,644 - Rv0451c 0.37 -2.7
541,801 + Rv0451c 0.74 +1.3
541,905 + +0.7
541,906 - +0.2
541,906 - +0.4
541,906 - -0.5
541,995 + -0.7
541,995 + +0.3
542,009 + +1.1
542,038 - -0.5
542,038 - +1.7
542,059 + -0.3
542,059 + -0.1
542,060 - +0.2
542,079 - -0.9
542,107 + -1.0
542,107 + +0.0
542,107 + -0.1
542,107 + -0.4
542,107 + -1.5
542,107 + -0.9
542,107 + -0.4
542,108 - -0.6
542,399 - Rv0452 0.36 -1.1

Or see this region's nucleotide sequence