Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3538

Experiment: 7H9 with Doxycycline hyclate 0.0035 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3537 and Rv3538 are separated by 1 nucleotidesRv3538 and Rv3539 are separated by 136 nucleotides Rv3537: Rv3537 - Probable dehydrogenase, at 3,975,369 to 3,977,060 Rv3537 Rv3538: Rv3538 - Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase., at 3,977,062 to 3,977,922 Rv3538 Rv3539: Rv3539 - PPE family protein PPE63, at 3,978,059 to 3,979,498 Rv3539 Position (kb) 3977 3978Strain fitness (log2 ratio) -2 -1 0 1 2at 3976.464 kb on - strand, within Rv3537at 3976.752 kb on + strand, within Rv3537at 3976.762 kb on - strand, within Rv3537at 3976.822 kb on - strand, within Rv3537at 3976.994 kb on - strandat 3977.211 kb on + strand, within Rv3538at 3977.708 kb on - strand, within Rv3538at 3977.991 kb on - strandat 3978.108 kb on - strandat 3978.375 kb on + strand, within Rv3539at 3978.376 kb on - strand, within Rv3539at 3978.479 kb on + strand, within Rv3539at 3978.480 kb on - strand, within Rv3539at 3978.521 kb on + strand, within Rv3539at 3978.522 kb on - strand, within Rv3539at 3978.664 kb on + strand, within Rv3539at 3978.803 kb on + strand, within Rv3539

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Doxycycline hyclate 0.0035 mM
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3,976,464 - Rv3537 0.65 +0.1
3,976,752 + Rv3537 0.82 -1.2
3,976,762 - Rv3537 0.82 -1.5
3,976,822 - Rv3537 0.86 +0.2
3,976,994 - +1.8
3,977,211 + Rv3538 0.17 -2.0
3,977,708 - Rv3538 0.75 +0.3
3,977,991 - -0.0
3,978,108 - -0.3
3,978,375 + Rv3539 0.22 +0.0
3,978,376 - Rv3539 0.22 -0.2
3,978,479 + Rv3539 0.29 -1.0
3,978,480 - Rv3539 0.29 +0.3
3,978,521 + Rv3539 0.32 +1.4
3,978,522 - Rv3539 0.32 -0.5
3,978,664 + Rv3539 0.42 -0.0
3,978,803 + Rv3539 0.52 -0.4

Or see this region's nucleotide sequence