Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2434c

Experiment: 7H9 with Doxycycline hyclate 0.0035 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2431c and Rv2432c are separated by 170 nucleotidesRv2432c and Rv2433c overlap by 4 nucleotidesRv2433c and Rv2434c overlap by 20 nucleotidesRv2434c and Rv2435c overlap by 4 nucleotides Rv2431c: Rv2431c - PE family protein PE25, at 2,727,967 to 2,728,266 Rv2431c Rv2432c: Rv2432c - Hypothetical protein, at 2,728,437 to 2,728,847 Rv2432c Rv2433c: Rv2433c - Hypothetical protein, at 2,728,844 to 2,729,134 Rv2433c Rv2434c: Rv2434c - Probable conserved transmembrane protein, at 2,729,115 to 2,730,560 Rv2434c Rv2435c: Rv2435c - Probable cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-), at 2,730,557 to 2,732,749 Rv2435c Position (kb) 2729 2730 2731Strain fitness (log2 ratio) -1 0 1 2at 2728.379 kb on + strandat 2728.379 kb on + strandat 2728.383 kb on + strandat 2728.384 kb on - strandat 2728.498 kb on + strand, within Rv2432cat 2728.504 kb on - strand, within Rv2432cat 2728.681 kb on - strand, within Rv2432cat 2728.938 kb on + strand, within Rv2433cat 2729.015 kb on + strand, within Rv2433cat 2729.015 kb on + strand, within Rv2433cat 2729.015 kb on + strand, within Rv2433cat 2729.657 kb on - strand, within Rv2434cat 2729.821 kb on - strand, within Rv2434cat 2730.465 kb on + strandat 2730.580 kb on - strandat 2730.673 kb on - strandat 2730.741 kb on + strandat 2730.887 kb on - strand, within Rv2435cat 2730.927 kb on + strand, within Rv2435cat 2731.518 kb on + strand, within Rv2435c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Doxycycline hyclate 0.0035 mM
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2,728,379 + +1.8
2,728,379 + -0.8
2,728,383 + +1.2
2,728,384 - +0.2
2,728,498 + Rv2432c 0.15 +0.2
2,728,504 - Rv2432c 0.16 -0.6
2,728,681 - Rv2432c 0.59 -0.2
2,728,938 + Rv2433c 0.32 +0.1
2,729,015 + Rv2433c 0.59 -0.1
2,729,015 + Rv2433c 0.59 -0.1
2,729,015 + Rv2433c 0.59 +0.6
2,729,657 - Rv2434c 0.37 -1.1
2,729,821 - Rv2434c 0.49 -0.6
2,730,465 + -0.4
2,730,580 - +0.4
2,730,673 - -0.5
2,730,741 + +0.4
2,730,887 - Rv2435c 0.15 +0.6
2,730,927 + Rv2435c 0.17 -1.0
2,731,518 + Rv2435c 0.44 -0.2

Or see this region's nucleotide sequence