Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0339c

Experiment: 7H9 with Doxycycline hyclate 0.0035 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0338c and Rv0339c are separated by 108 nucleotidesRv0339c and Rv0340 are separated by 185 nucleotidesRv0340 and Rv0341 are separated by 188 nucleotides Rv0338c: Rv0338c - Probable iron-sulfur-binding reductase, at 403,193 to 405,841 Rv0338c Rv0339c: Rv0339c - Possible transcriptional regulatory protein, at 405,950 to 408,448 Rv0339c Rv0340: Rv0340 - Conserved protein, at 408,634 to 409,173 Rv0340 Rv0341: Rv0341 - Isoniazid inductible gene protein IniB, at 409,362 to 410,801 Rv0341 Position (kb) 405 406 407 408 409Strain fitness (log2 ratio) -2 -1 0 1 2at 405.885 kb on - strandat 405.885 kb on - strandat 405.885 kb on - strandat 405.937 kb on - strandat 406.124 kb on + strandat 406.130 kb on + strandat 406.130 kb on + strandat 406.264 kb on + strand, within Rv0339cat 406.638 kb on - strand, within Rv0339cat 406.716 kb on + strand, within Rv0339cat 406.743 kb on + strand, within Rv0339cat 406.744 kb on - strand, within Rv0339cat 407.006 kb on + strand, within Rv0339cat 407.109 kb on + strand, within Rv0339cat 407.405 kb on + strand, within Rv0339cat 407.607 kb on - strand, within Rv0339cat 407.629 kb on + strand, within Rv0339cat 408.412 kb on - strandat 408.477 kb on - strandat 408.585 kb on - strandat 408.595 kb on + strandat 409.132 kb on - strandat 409.172 kb on - strandat 409.208 kb on + strandat 409.209 kb on - strandat 409.242 kb on + strandat 409.381 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Doxycycline hyclate 0.0035 mM
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405,885 - +1.8
405,885 - -1.9
405,885 - -1.8
405,937 - -0.0
406,124 + -0.2
406,130 + -0.4
406,130 + -0.4
406,264 + Rv0339c 0.13 +0.2
406,638 - Rv0339c 0.28 +0.7
406,716 + Rv0339c 0.31 +0.3
406,743 + Rv0339c 0.32 +0.1
406,744 - Rv0339c 0.32 +1.9
407,006 + Rv0339c 0.42 -0.0
407,109 + Rv0339c 0.46 -0.2
407,405 + Rv0339c 0.58 -0.1
407,607 - Rv0339c 0.66 -0.2
407,629 + Rv0339c 0.67 +0.8
408,412 - -0.8
408,477 - -0.5
408,585 - -0.5
408,595 + +1.8
409,132 - -0.7
409,172 - -0.2
409,208 + -0.5
409,209 - +0.2
409,242 + -0.2
409,381 - +0.3

Or see this region's nucleotide sequence