Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1739c

Experiment: 7H9 with Doxycycline hyclate 0.0035 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1737c and Rv1738 are separated by 286 nucleotidesRv1738 and Rv1739c are separated by 13 nucleotidesRv1739c and Rv1740 are separated by 67 nucleotidesRv1740 and Rv1741 overlap by 1 nucleotidesRv1741 and Rv1742 are separated by 7 nucleotides Rv1737c: Rv1737c - Possible nitrate/nitrite transporter NarK2, at 1,964,183 to 1,965,370 Rv1737c Rv1738: Rv1738 - Conserved protein, at 1,965,657 to 1,965,941 Rv1738 Rv1739c: Rv1739c - Probable sulphate-transport transmembrane protein ABC transporter, at 1,965,955 to 1,967,637 Rv1739c Rv1740: Rv1740 - Possible antitoxin VapB34, at 1,967,705 to 1,967,917 Rv1740 Rv1741: Rv1741 - Possible toxin VapC34. Contains PIN domain., at 1,967,917 to 1,968,165 Rv1741 Rv1742: Rv1742 - Unknown protein, at 1,968,173 to 1,968,910 Rv1742 Position (kb) 1965 1966 1967 1968Strain fitness (log2 ratio) -2 -1 0 1 2at 1964.956 kb on + strand, within Rv1737cat 1965.081 kb on + strand, within Rv1737cat 1965.277 kb on - strandat 1965.584 kb on + strandat 1965.585 kb on - strandat 1965.936 kb on + strandat 1965.937 kb on - strandat 1966.430 kb on + strand, within Rv1739cat 1966.431 kb on - strand, within Rv1739cat 1966.448 kb on - strand, within Rv1739cat 1966.538 kb on - strand, within Rv1739cat 1966.538 kb on - strand, within Rv1739cat 1966.548 kb on - strand, within Rv1739cat 1966.549 kb on + strand, within Rv1739cat 1966.550 kb on - strand, within Rv1739cat 1967.044 kb on - strand, within Rv1739cat 1967.047 kb on + strand, within Rv1739cat 1967.048 kb on - strand, within Rv1739cat 1967.122 kb on + strand, within Rv1739cat 1967.213 kb on + strand, within Rv1739cat 1967.213 kb on + strand, within Rv1739cat 1967.286 kb on + strand, within Rv1739cat 1967.327 kb on + strand, within Rv1739cat 1967.435 kb on + strand, within Rv1739cat 1967.501 kb on + strandat 1967.501 kb on + strandat 1967.579 kb on + strandat 1967.657 kb on + strandat 1967.672 kb on + strandat 1967.692 kb on + strandat 1967.693 kb on - strandat 1967.751 kb on + strand, within Rv1740at 1967.985 kb on - strand, within Rv1741at 1968.112 kb on + strand, within Rv1741at 1968.114 kb on + strand, within Rv1741at 1968.135 kb on + strand, within Rv1741at 1968.136 kb on - strand, within Rv1741at 1968.141 kb on + strandat 1968.518 kb on + strand, within Rv1742at 1968.519 kb on - strand, within Rv1742at 1968.545 kb on + strand, within Rv1742at 1968.561 kb on - strand, within Rv1742

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Doxycycline hyclate 0.0035 mM
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1,964,956 + Rv1737c 0.65 -0.0
1,965,081 + Rv1737c 0.76 +2.4
1,965,277 - -2.0
1,965,584 + -0.6
1,965,585 - -1.2
1,965,936 + -0.2
1,965,937 - -0.1
1,966,430 + Rv1739c 0.28 -0.1
1,966,431 - Rv1739c 0.28 +0.1
1,966,448 - Rv1739c 0.29 -0.1
1,966,538 - Rv1739c 0.35 +0.1
1,966,538 - Rv1739c 0.35 +0.8
1,966,548 - Rv1739c 0.35 +0.0
1,966,549 + Rv1739c 0.35 -1.1
1,966,550 - Rv1739c 0.35 +1.4
1,967,044 - Rv1739c 0.65 +0.9
1,967,047 + Rv1739c 0.65 -1.4
1,967,048 - Rv1739c 0.65 +0.8
1,967,122 + Rv1739c 0.69 -0.1
1,967,213 + Rv1739c 0.75 +0.6
1,967,213 + Rv1739c 0.75 -1.2
1,967,286 + Rv1739c 0.79 +0.5
1,967,327 + Rv1739c 0.82 +0.7
1,967,435 + Rv1739c 0.88 +0.1
1,967,501 + -0.2
1,967,501 + +0.0
1,967,579 + +0.4
1,967,657 + -1.1
1,967,672 + -0.5
1,967,692 + -0.6
1,967,693 - +0.5
1,967,751 + Rv1740 0.22 +0.3
1,967,985 - Rv1741 0.27 -0.7
1,968,112 + Rv1741 0.78 -0.8
1,968,114 + Rv1741 0.79 +0.0
1,968,135 + Rv1741 0.88 +0.1
1,968,136 - Rv1741 0.88 +1.7
1,968,141 + -0.9
1,968,518 + Rv1742 0.47 -0.4
1,968,519 - Rv1742 0.47 -0.5
1,968,545 + Rv1742 0.50 +0.2
1,968,561 - Rv1742 0.53 -1.3

Or see this region's nucleotide sequence