Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0181c

Experiment: 7H9 with Doxycycline hyclate 0.0035 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0180c and Rv0181c are separated by 26 nucleotidesRv0181c and Rv0182c are separated by 16 nucleotides Rv0180c: Rv0180c - Probable conserved transmembrane protein, at 210,892 to 212,250 Rv0180c Rv0181c: Rv0181c - Conserved hypothetical protein, at 212,277 to 213,011 Rv0181c Rv0182c: Rv0182c - Probable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor), at 213,028 to 214,140 Rv0182c Position (kb) 212 213 214Strain fitness (log2 ratio) -2 -1 0 1 2at 212.278 kb on + strandat 212.278 kb on + strandat 212.278 kb on + strandat 212.278 kb on + strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.323 kb on - strandat 212.569 kb on - strand, within Rv0181cat 212.598 kb on + strand, within Rv0181cat 212.599 kb on - strand, within Rv0181cat 212.614 kb on + strand, within Rv0181cat 212.615 kb on - strand, within Rv0181cat 212.615 kb on - strand, within Rv0181cat 212.644 kb on - strand, within Rv0181cat 212.747 kb on - strand, within Rv0181cat 212.914 kb on + strand, within Rv0181cat 212.915 kb on - strand, within Rv0181cat 212.991 kb on + strandat 212.992 kb on - strandat 213.124 kb on + strandat 213.161 kb on + strand, within Rv0182cat 213.161 kb on + strand, within Rv0182cat 213.162 kb on - strand, within Rv0182cat 213.162 kb on - strand, within Rv0182cat 213.275 kb on + strand, within Rv0182cat 213.287 kb on + strand, within Rv0182cat 213.287 kb on + strand, within Rv0182cat 213.287 kb on + strand, within Rv0182cat 213.288 kb on - strand, within Rv0182cat 213.348 kb on - strand, within Rv0182cat 213.367 kb on - strand, within Rv0182cat 213.367 kb on - strand, within Rv0182cat 213.475 kb on - strand, within Rv0182cat 213.475 kb on - strand, within Rv0182cat 213.554 kb on - strand, within Rv0182cat 213.821 kb on - strand, within Rv0182cat 213.848 kb on + strand, within Rv0182cat 213.849 kb on - strand, within Rv0182cat 213.849 kb on - strand, within Rv0182cat 213.849 kb on - strand, within Rv0182cat 213.921 kb on - strand, within Rv0182c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Doxycycline hyclate 0.0035 mM
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212,278 + +0.6
212,278 + -0.9
212,278 + -0.3
212,278 + -0.8
212,279 - +0.6
212,279 - -1.1
212,279 - +0.8
212,279 - -0.3
212,279 - +1.1
212,279 - -1.0
212,323 - +0.2
212,569 - Rv0181c 0.40 -0.3
212,598 + Rv0181c 0.44 -0.7
212,599 - Rv0181c 0.44 -0.5
212,614 + Rv0181c 0.46 -0.8
212,615 - Rv0181c 0.46 -1.2
212,615 - Rv0181c 0.46 -0.5
212,644 - Rv0181c 0.50 -1.2
212,747 - Rv0181c 0.64 +0.5
212,914 + Rv0181c 0.87 +1.6
212,915 - Rv0181c 0.87 -0.6
212,991 + -0.5
212,992 - -0.5
213,124 + -0.1
213,161 + Rv0182c 0.12 -0.2
213,161 + Rv0182c 0.12 -1.9
213,162 - Rv0182c 0.12 +0.1
213,162 - Rv0182c 0.12 -0.4
213,275 + Rv0182c 0.22 -1.7
213,287 + Rv0182c 0.23 -0.8
213,287 + Rv0182c 0.23 -1.0
213,287 + Rv0182c 0.23 -0.5
213,288 - Rv0182c 0.23 +0.0
213,348 - Rv0182c 0.29 -0.1
213,367 - Rv0182c 0.30 -0.4
213,367 - Rv0182c 0.30 -1.3
213,475 - Rv0182c 0.40 +1.8
213,475 - Rv0182c 0.40 +0.8
213,554 - Rv0182c 0.47 +1.2
213,821 - Rv0182c 0.71 -0.3
213,848 + Rv0182c 0.74 -0.7
213,849 - Rv0182c 0.74 -0.4
213,849 - Rv0182c 0.74 -0.3
213,849 - Rv0182c 0.74 -0.4
213,921 - Rv0182c 0.80 +1.3

Or see this region's nucleotide sequence