Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2489c

Experiment: cholesterol 100uM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2488c and Rv2489c overlap by 35 nucleotidesRv2489c and Rv2490c are separated by 108 nucleotides Rv2488c: Rv2488c - Probable transcriptional regulatory protein (LuxR-family), at 2,797,467 to 2,800,880 Rv2488c Rv2489c: Rv2489c - Hypothetical alanine rich protein, at 2,800,846 to 2,801,145 Rv2489c Rv2490c: Rv2490c - PE-PGRS family protein PE_PGRS43, at 2,801,254 to 2,806,236 Rv2490c Position (kb) 2800 2801 2802Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3at 2799.867 kb on + strand, within Rv2488cat 2799.867 kb on + strand, within Rv2488cat 2800.288 kb on + strand, within Rv2488cat 2800.293 kb on - strand, within Rv2488cat 2800.350 kb on - strand, within Rv2488cat 2800.422 kb on + strand, within Rv2488cat 2800.829 kb on + strandat 2800.830 kb on - strandat 2800.847 kb on + strandat 2800.938 kb on + strand, within Rv2489cat 2800.938 kb on + strand, within Rv2489cat 2800.938 kb on + strand, within Rv2489cat 2800.939 kb on - strand, within Rv2489cat 2800.939 kb on - strand, within Rv2489cat 2800.939 kb on - strand, within Rv2489cat 2801.092 kb on - strand, within Rv2489cat 2801.164 kb on + strandat 2801.255 kb on + strandat 2801.789 kb on + strand, within Rv2490cat 2801.793 kb on + strand, within Rv2490cat 2801.793 kb on + strand, within Rv2490cat 2801.793 kb on + strand, within Rv2490cat 2801.793 kb on + strand, within Rv2490cat 2801.794 kb on - strand, within Rv2490cat 2801.820 kb on + strand, within Rv2490cat 2801.820 kb on + strand, within Rv2490cat 2801.989 kb on - strand, within Rv2490cat 2802.038 kb on - strand, within Rv2490cat 2802.038 kb on - strand, within Rv2490c

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Per-strain Table

Position Strand Gene LocusTag Fraction cholesterol 100uM (C)
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2,799,867 + Rv2488c 0.70 -0.3
2,799,867 + Rv2488c 0.70 +3.0
2,800,288 + Rv2488c 0.83 -0.2
2,800,293 - Rv2488c 0.83 -0.3
2,800,350 - Rv2488c 0.84 +0.5
2,800,422 + Rv2488c 0.87 -0.2
2,800,829 + -0.4
2,800,830 - -0.6
2,800,847 + -2.4
2,800,938 + Rv2489c 0.31 -0.8
2,800,938 + Rv2489c 0.31 -3.0
2,800,938 + Rv2489c 0.31 -0.2
2,800,939 - Rv2489c 0.31 -3.1
2,800,939 - Rv2489c 0.31 -0.9
2,800,939 - Rv2489c 0.31 +1.1
2,801,092 - Rv2489c 0.82 -0.4
2,801,164 + -0.2
2,801,255 + -0.2
2,801,789 + Rv2490c 0.11 +0.2
2,801,793 + Rv2490c 0.11 -1.2
2,801,793 + Rv2490c 0.11 -0.4
2,801,793 + Rv2490c 0.11 -0.2
2,801,793 + Rv2490c 0.11 +1.0
2,801,794 - Rv2490c 0.11 -1.2
2,801,820 + Rv2490c 0.11 -1.4
2,801,820 + Rv2490c 0.11 -0.2
2,801,989 - Rv2490c 0.15 +0.4
2,802,038 - Rv2490c 0.16 -0.2
2,802,038 - Rv2490c 0.16 +0.5

Or see this region's nucleotide sequence