Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3570c

Experiment: cholesterol 100uM (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3568c and Rv3569c overlap by 4 nucleotidesRv3569c and Rv3570c are separated by 14 nucleotidesRv3570c and Rv3571 are separated by 146 nucleotides Rv3568c: Rv3568c - 3,4-DHSA dioxygenase, at 4,009,297 to 4,010,199 Rv3568c Rv3569c: Rv3569c - 4,9-DHSA hydrolase, at 4,010,196 to 4,011,071 Rv3569c Rv3570c: Rv3570c - Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase., at 4,011,086 to 4,012,270 Rv3570c Rv3571: Rv3571 - Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB, at 4,012,417 to 4,013,493 Rv3571 Position (kb) 4011 4012 4013Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 4010.283 kb on + strandat 4010.283 kb on + strandat 4010.642 kb on + strand, within Rv3569cat 4010.643 kb on - strand, within Rv3569cat 4010.693 kb on - strand, within Rv3569cat 4010.989 kb on + strandat 4011.062 kb on + strandat 4011.141 kb on + strandat 4011.141 kb on + strandat 4011.584 kb on - strand, within Rv3570cat 4011.710 kb on + strand, within Rv3570cat 4011.710 kb on + strand, within Rv3570cat 4011.711 kb on - strand, within Rv3570cat 4011.723 kb on + strand, within Rv3570cat 4011.723 kb on + strand, within Rv3570cat 4011.724 kb on - strand, within Rv3570cat 4012.272 kb on + strandat 4012.272 kb on + strandat 4012.342 kb on - strandat 4012.615 kb on - strand, within Rv3571at 4012.960 kb on + strand, within Rv3571at 4012.961 kb on - strand, within Rv3571at 4013.048 kb on - strand, within Rv3571

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Per-strain Table

Position Strand Gene LocusTag Fraction cholesterol 100uM (C)
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4,010,283 + -3.7
4,010,283 + -2.2
4,010,642 + Rv3569c 0.51 -2.4
4,010,643 - Rv3569c 0.51 -1.2
4,010,693 - Rv3569c 0.57 +1.9
4,010,989 + +0.4
4,011,062 + -1.1
4,011,141 + -0.2
4,011,141 + -3.0
4,011,584 - Rv3570c 0.42 -3.2
4,011,710 + Rv3570c 0.53 -1.5
4,011,710 + Rv3570c 0.53 -1.5
4,011,711 - Rv3570c 0.53 -2.2
4,011,723 + Rv3570c 0.54 -2.5
4,011,723 + Rv3570c 0.54 -1.8
4,011,724 - Rv3570c 0.54 -3.1
4,012,272 + -3.3
4,012,272 + -2.9
4,012,342 - +1.3
4,012,615 - Rv3571 0.18 -0.1
4,012,960 + Rv3571 0.50 -2.9
4,012,961 - Rv3571 0.51 -1.3
4,013,048 - Rv3571 0.59 -2.5

Or see this region's nucleotide sequence