Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3411c

Experiment: 7H9 with Pyrazinamide 50 ug/mL; pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3410c and Rv3411c are separated by 19 nucleotidesRv3411c and Rv3412 are separated by 206 nucleotidesRv3412 and Rv3413c are separated by 9 nucleotides Rv3410c: Rv3410c - Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD), at 3,828,783 to 3,829,910 Rv3410c Rv3411c: Rv3411c - Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD), at 3,829,930 to 3,831,519 Rv3411c Rv3412: Rv3412 - Conserved hypothetical protein, at 3,831,726 to 3,832,136 Rv3412 Rv3413c: Rv3413c - Unknown alanine and proline rich protein, at 3,832,146 to 3,833,045 Rv3413c Position (kb) 3829 3830 3831 3832Strain fitness (log2 ratio) -2 -1 0 1at 3829.941 kb on - strandat 3831.574 kb on + strandat 3831.714 kb on + strandat 3831.715 kb on - strandat 3831.719 kb on + strandat 3831.719 kb on + strandat 3831.720 kb on - strandat 3831.919 kb on + strand, within Rv3412at 3831.919 kb on + strand, within Rv3412at 3831.951 kb on + strand, within Rv3412at 3831.952 kb on - strand, within Rv3412at 3831.952 kb on - strand, within Rv3412at 3831.995 kb on + strand, within Rv3412at 3831.996 kb on - strand, within Rv3412at 3832.051 kb on - strand, within Rv3412at 3832.484 kb on + strand, within Rv3413cat 3832.485 kb on - strand, within Rv3413c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Pyrazinamide 50 ug/mL; pH 5.5
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3,829,941 - -0.1
3,831,574 + +1.7
3,831,714 + -0.3
3,831,715 - -2.4
3,831,719 + +0.9
3,831,719 + -0.8
3,831,720 - +1.7
3,831,919 + Rv3412 0.47 -0.2
3,831,919 + Rv3412 0.47 -0.8
3,831,951 + Rv3412 0.55 -1.6
3,831,952 - Rv3412 0.55 -0.3
3,831,952 - Rv3412 0.55 +1.7
3,831,995 + Rv3412 0.65 +0.4
3,831,996 - Rv3412 0.66 +0.6
3,832,051 - Rv3412 0.79 +0.1
3,832,484 + Rv3413c 0.38 +1.1
3,832,485 - Rv3413c 0.38 +0.3

Or see this region's nucleotide sequence