Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1187

Experiment: 7H9 with Pyrazinamide 50 ug/mL; pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1186c and Rv1187 are separated by 84 nucleotidesRv1187 and Rv1188 overlap by 1 nucleotides Rv1186c: Rv1186c - Conserved protein, at 1,327,689 to 1,329,305 Rv1186c Rv1187: Rv1187 - Probable pyrroline-5-carboxylate dehydrogenase RocA, at 1,329,390 to 1,331,021 Rv1187 Rv1188: Rv1188 - Probable proline dehydrogenase, at 1,331,021 to 1,332,010 Rv1188 Position (kb) 1329 1330 1331 1332Strain fitness (log2 ratio) -1 0 1at 1328.430 kb on + strand, within Rv1186cat 1328.719 kb on - strand, within Rv1186cat 1328.804 kb on - strand, within Rv1186cat 1328.956 kb on + strand, within Rv1186cat 1329.321 kb on + strandat 1330.837 kb on - strand, within Rv1187at 1331.822 kb on + strand, within Rv1188at 1331.882 kb on + strand, within Rv1188at 1331.883 kb on - strand, within Rv1188

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Pyrazinamide 50 ug/mL; pH 5.5
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1,328,430 + Rv1186c 0.46 -0.6
1,328,719 - Rv1186c 0.64 -0.8
1,328,804 - Rv1186c 0.69 +0.7
1,328,956 + Rv1186c 0.78 +1.7
1,329,321 + +0.1
1,330,837 - Rv1187 0.89 +0.3
1,331,822 + Rv1188 0.81 -0.1
1,331,882 + Rv1188 0.87 -0.6
1,331,883 - Rv1188 0.87 -0.2

Or see this region's nucleotide sequence