Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1178

Experiment: 7H9 with Pyrazinamide 50 ug/mL; pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1176c and Rv1177 are separated by 212 nucleotidesRv1177 and Rv1178 are separated by 32 nucleotidesRv1178 and Rv1179c are separated by 27 nucleotides Rv1176c: Rv1176c - Conserved hypothetical protein, at 1,308,223 to 1,308,792 Rv1176c Rv1177: Rv1177 - Probable ferredoxin FdxC, at 1,309,005 to 1,309,331 Rv1177 Rv1178: Rv1178 - Probable aminotransferase, at 1,309,364 to 1,310,452 Rv1178 Rv1179c: Rv1179c - Unknown protein, at 1,310,480 to 1,313,299 Rv1179c Position (kb) 1309 1310 1311Strain fitness (log2 ratio) -2 -1 0 1at 1308.426 kb on + strand, within Rv1176cat 1308.589 kb on + strand, within Rv1176cat 1308.589 kb on + strand, within Rv1176cat 1308.589 kb on + strand, within Rv1176cat 1308.671 kb on + strand, within Rv1176cat 1308.672 kb on - strand, within Rv1176cat 1308.738 kb on - strandat 1308.831 kb on + strandat 1308.840 kb on - strandat 1308.840 kb on - strandat 1308.840 kb on - strandat 1308.850 kb on + strandat 1308.896 kb on - strandat 1308.898 kb on + strandat 1308.970 kb on + strandat 1308.970 kb on + strandat 1308.976 kb on + strandat 1308.976 kb on + strandat 1308.976 kb on + strandat 1308.976 kb on + strandat 1309.719 kb on - strand, within Rv1178at 1309.815 kb on - strand, within Rv1178at 1309.966 kb on - strand, within Rv1178at 1310.094 kb on + strand, within Rv1178at 1310.095 kb on - strand, within Rv1178at 1310.147 kb on - strand, within Rv1178at 1310.280 kb on + strand, within Rv1178at 1310.281 kb on - strand, within Rv1178at 1310.801 kb on + strand, within Rv1179cat 1310.801 kb on + strand, within Rv1179cat 1310.802 kb on - strand, within Rv1179cat 1311.280 kb on - strand, within Rv1179cat 1311.447 kb on + strand, within Rv1179cat 1311.448 kb on - strand, within Rv1179c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Pyrazinamide 50 ug/mL; pH 5.5
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1,308,426 + Rv1176c 0.36 -0.7
1,308,589 + Rv1176c 0.64 +0.6
1,308,589 + Rv1176c 0.64 -0.4
1,308,589 + Rv1176c 0.64 +0.1
1,308,671 + Rv1176c 0.79 +0.2
1,308,672 - Rv1176c 0.79 -0.9
1,308,738 - +0.4
1,308,831 + +0.8
1,308,840 - +0.8
1,308,840 - +1.7
1,308,840 - +0.0
1,308,850 + -0.8
1,308,896 - -0.1
1,308,898 + +0.0
1,308,970 + -1.8
1,308,970 + -0.3
1,308,976 + +0.5
1,308,976 + -0.2
1,308,976 + -0.2
1,308,976 + +0.6
1,309,719 - Rv1178 0.33 -0.3
1,309,815 - Rv1178 0.41 -1.2
1,309,966 - Rv1178 0.55 -0.9
1,310,094 + Rv1178 0.67 -1.0
1,310,095 - Rv1178 0.67 -0.4
1,310,147 - Rv1178 0.72 -1.7
1,310,280 + Rv1178 0.84 +0.1
1,310,281 - Rv1178 0.84 +0.1
1,310,801 + Rv1179c 0.11 -2.2
1,310,801 + Rv1179c 0.11 +1.4
1,310,802 - Rv1179c 0.11 +0.9
1,311,280 - Rv1179c 0.28 -0.4
1,311,447 + Rv1179c 0.34 +0.3
1,311,448 - Rv1179c 0.34 +0.1

Or see this region's nucleotide sequence