Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1113

Experiment: 7H9 pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1112 and Rv1113 are separated by 87 nucleotidesRv1113 and Rv1114 overlap by 4 nucleotidesRv1114 and Rv1115 are separated by 202 nucleotides Rv1112: Rv1112 - Probable GTP binding protein, at 1,238,255 to 1,239,328 Rv1112 Rv1113: Rv1113 - Possible antitoxin VapB32, at 1,239,416 to 1,239,613 Rv1113 Rv1114: Rv1114 - Possible toxin VapC32. Contains PIN domain., at 1,239,610 to 1,239,984 Rv1114 Rv1115: Rv1115 - Possible exported protein, at 1,240,187 to 1,240,885 Rv1115 Position (kb) 1239 1240Strain fitness (log2 ratio) -2 -1 0 1 2at 1238.853 kb on - strand, within Rv1112at 1238.853 kb on - strand, within Rv1112at 1238.853 kb on - strand, within Rv1112at 1239.282 kb on - strandat 1239.303 kb on + strandat 1239.327 kb on - strandat 1239.327 kb on - strandat 1239.451 kb on - strand, within Rv1113at 1239.782 kb on - strand, within Rv1114at 1239.911 kb on + strand, within Rv1114at 1239.989 kb on + strandat 1239.989 kb on + strandat 1239.989 kb on + strandat 1239.990 kb on - strandat 1240.298 kb on + strand, within Rv1115at 1240.393 kb on + strand, within Rv1115at 1240.393 kb on + strand, within Rv1115at 1240.394 kb on - strand, within Rv1115at 1240.394 kb on - strand, within Rv1115at 1240.598 kb on + strand, within Rv1115

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 pH 5.5
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1,238,853 - Rv1112 0.56 -2.2
1,238,853 - Rv1112 0.56 -0.9
1,238,853 - Rv1112 0.56 +1.7
1,239,282 - -0.7
1,239,303 + +2.7
1,239,327 - -1.0
1,239,327 - +1.3
1,239,451 - Rv1113 0.18 +0.7
1,239,782 - Rv1114 0.46 +0.1
1,239,911 + Rv1114 0.80 +0.0
1,239,989 + -0.2
1,239,989 + -1.6
1,239,989 + -0.1
1,239,990 - +1.7
1,240,298 + Rv1115 0.16 -0.9
1,240,393 + Rv1115 0.29 +0.2
1,240,393 + Rv1115 0.29 -0.3
1,240,394 - Rv1115 0.30 +0.0
1,240,394 - Rv1115 0.30 +0.8
1,240,598 + Rv1115 0.59 +0.6

Or see this region's nucleotide sequence