Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3720

Experiment: 7H9 with Cumene hydroperoxide 0.05 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3719 and Rv3720 are separated by 17 nucleotidesRv3720 and Rv3721c overlap by 4 nucleotides Rv3719: Rv3719 - Conserved protein, at 4,162,306 to 4,163,718 Rv3719 Rv3720: Rv3720 - Possible fatty acid synthase, at 4,163,736 to 4,164,998 Rv3720 Rv3721c: Rv3721c - DNA polymerase III (subunit gamma/tau) DnaZ/X, at 4,164,995 to 4,166,731 Rv3721c Position (kb) 4163 4164 4165Strain fitness (log2 ratio) -2 -1 0 1 2at 4162.789 kb on + strand, within Rv3719at 4162.970 kb on - strand, within Rv3719at 4162.970 kb on - strand, within Rv3719at 4163.005 kb on + strand, within Rv3719at 4163.006 kb on - strand, within Rv3719at 4163.053 kb on + strand, within Rv3719at 4163.071 kb on + strand, within Rv3719at 4163.072 kb on - strand, within Rv3719at 4163.072 kb on - strand, within Rv3719at 4163.131 kb on + strand, within Rv3719at 4163.472 kb on + strand, within Rv3719at 4163.477 kb on - strand, within Rv3719at 4163.477 kb on - strand, within Rv3719at 4163.599 kb on + strandat 4163.642 kb on - strandat 4163.642 kb on - strandat 4163.663 kb on - strandat 4163.872 kb on + strand, within Rv3720at 4163.873 kb on - strand, within Rv3720at 4163.911 kb on - strand, within Rv3720at 4163.941 kb on + strand, within Rv3720at 4163.941 kb on + strand, within Rv3720at 4163.941 kb on + strand, within Rv3720at 4163.942 kb on - strand, within Rv3720at 4164.055 kb on + strand, within Rv3720at 4164.163 kb on - strand, within Rv3720at 4164.213 kb on + strand, within Rv3720at 4164.274 kb on - strand, within Rv3720at 4164.320 kb on - strand, within Rv3720at 4164.564 kb on + strand, within Rv3720at 4164.564 kb on + strand, within Rv3720at 4164.713 kb on + strand, within Rv3720at 4164.716 kb on + strand, within Rv3720at 4164.717 kb on - strand, within Rv3720at 4164.876 kb on + strandat 4164.876 kb on + strandat 4164.877 kb on - strandat 4164.877 kb on - strandat 4164.922 kb on + strandat 4164.931 kb on + strandat 4164.931 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Cumene hydroperoxide 0.05 mM
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4,162,789 + Rv3719 0.34 -1.2
4,162,970 - Rv3719 0.47 -0.7
4,162,970 - Rv3719 0.47 +0.1
4,163,005 + Rv3719 0.49 -2.7
4,163,006 - Rv3719 0.50 -1.0
4,163,053 + Rv3719 0.53 -0.3
4,163,071 + Rv3719 0.54 +1.1
4,163,072 - Rv3719 0.54 -1.6
4,163,072 - Rv3719 0.54 +1.5
4,163,131 + Rv3719 0.58 +0.1
4,163,472 + Rv3719 0.83 +0.5
4,163,477 - Rv3719 0.83 -0.9
4,163,477 - Rv3719 0.83 +0.9
4,163,599 + -0.8
4,163,642 - +1.1
4,163,642 - +1.3
4,163,663 - -0.1
4,163,872 + Rv3720 0.11 +1.5
4,163,873 - Rv3720 0.11 +1.1
4,163,911 - Rv3720 0.14 -0.0
4,163,941 + Rv3720 0.16 +0.5
4,163,941 + Rv3720 0.16 -0.1
4,163,941 + Rv3720 0.16 +0.5
4,163,942 - Rv3720 0.16 +0.2
4,164,055 + Rv3720 0.25 -0.3
4,164,163 - Rv3720 0.34 -0.6
4,164,213 + Rv3720 0.38 +2.1
4,164,274 - Rv3720 0.43 -0.8
4,164,320 - Rv3720 0.46 -0.8
4,164,564 + Rv3720 0.66 -0.4
4,164,564 + Rv3720 0.66 +0.1
4,164,713 + Rv3720 0.77 -1.0
4,164,716 + Rv3720 0.78 -0.5
4,164,717 - Rv3720 0.78 +0.2
4,164,876 + +0.5
4,164,876 + +0.2
4,164,877 - -0.4
4,164,877 - +0.2
4,164,922 + -0.5
4,164,931 + +1.8
4,164,931 + -1.1

Or see this region's nucleotide sequence