Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3174

Experiment: 7H9 with Cumene hydroperoxide 0.05 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3172c and Rv3173c are separated by 78 nucleotidesRv3173c and Rv3174 are separated by 92 nucleotidesRv3174 and Rv3175 are separated by 14 nucleotides Rv3172c: Rv3172c - Hypothetical protein, at 3,540,882 to 3,541,364 Rv3172c Rv3173c: Rv3173c - Probable transcriptional regulatory protein (probably TetR/AcrR-family), at 3,541,443 to 3,542,045 Rv3173c Rv3174: Rv3174 - Probable short-chain dehydrogenase/reductase, at 3,542,138 to 3,542,845 Rv3174 Rv3175: Rv3175 - Possible amidase (aminohydrolase), at 3,542,860 to 3,544,347 Rv3175 Position (kb) 3542 3543Strain fitness (log2 ratio) -2 -1 0 1 2 3 4at 3541.162 kb on - strand, within Rv3172cat 3541.268 kb on - strand, within Rv3172cat 3541.268 kb on - strand, within Rv3172cat 3541.289 kb on - strand, within Rv3172cat 3541.291 kb on + strand, within Rv3172cat 3541.291 kb on + strand, within Rv3172cat 3541.291 kb on + strand, within Rv3172cat 3541.375 kb on + strandat 3541.375 kb on + strandat 3541.634 kb on - strand, within Rv3173cat 3541.866 kb on - strand, within Rv3173cat 3541.983 kb on - strand, within Rv3173cat 3541.983 kb on - strand, within Rv3173cat 3542.045 kb on + strandat 3542.069 kb on + strandat 3542.091 kb on - strandat 3542.202 kb on - strandat 3542.561 kb on + strand, within Rv3174at 3542.649 kb on - strand, within Rv3174at 3542.839 kb on + strandat 3542.990 kb on - strandat 3543.127 kb on + strand, within Rv3175at 3543.127 kb on + strand, within Rv3175at 3543.127 kb on + strand, within Rv3175at 3543.127 kb on + strand, within Rv3175at 3543.178 kb on + strand, within Rv3175at 3543.178 kb on + strand, within Rv3175at 3543.178 kb on + strand, within Rv3175at 3543.179 kb on - strand, within Rv3175at 3543.182 kb on + strand, within Rv3175at 3543.183 kb on - strand, within Rv3175at 3543.183 kb on - strand, within Rv3175at 3543.395 kb on - strand, within Rv3175at 3543.635 kb on - strand, within Rv3175

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Cumene hydroperoxide 0.05 mM
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3,541,162 - Rv3172c 0.58 -0.3
3,541,268 - Rv3172c 0.80 -0.1
3,541,268 - Rv3172c 0.80 +0.5
3,541,289 - Rv3172c 0.84 -0.3
3,541,291 + Rv3172c 0.85 -0.6
3,541,291 + Rv3172c 0.85 -2.7
3,541,291 + Rv3172c 0.85 -0.9
3,541,375 + -0.6
3,541,375 + +0.0
3,541,634 - Rv3173c 0.32 -0.3
3,541,866 - Rv3173c 0.70 +0.2
3,541,983 - Rv3173c 0.90 -0.8
3,541,983 - Rv3173c 0.90 +1.6
3,542,045 + +0.3
3,542,069 + -0.9
3,542,091 - +1.0
3,542,202 - +0.7
3,542,561 + Rv3174 0.60 -0.1
3,542,649 - Rv3174 0.72 +1.2
3,542,839 + +3.1
3,542,990 - -0.1
3,543,127 + Rv3175 0.18 +4.7
3,543,127 + Rv3175 0.18 -0.6
3,543,127 + Rv3175 0.18 -0.0
3,543,127 + Rv3175 0.18 +0.4
3,543,178 + Rv3175 0.21 -1.0
3,543,178 + Rv3175 0.21 -0.1
3,543,178 + Rv3175 0.21 +0.8
3,543,179 - Rv3175 0.21 -0.8
3,543,182 + Rv3175 0.22 -0.3
3,543,183 - Rv3175 0.22 -0.5
3,543,183 - Rv3175 0.22 +1.2
3,543,395 - Rv3175 0.36 -0.8
3,543,635 - Rv3175 0.52 -0.2

Or see this region's nucleotide sequence