Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2260

Experiment: 7H9 with Cumene hydroperoxide 0.05 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2259 and Rv2260 overlap by 1 nucleotidesRv2260 and Rv2261c are separated by 76 nucleotidesRv2261c and Rv2262c are separated by 5 nucleotides Rv2259: Rv2259 - S-nitrosomycothiol reductase MscR, at 2,532,245 to 2,533,330 Rv2259 Rv2260: Rv2260 - Conserved hypothetical protein, at 2,533,330 to 2,533,965 Rv2260 Rv2261c: Rv2261c - Conserved hypothetical protein, at 2,534,042 to 2,534,464 Rv2261c Rv2262c: Rv2262c - Conserved hypothetical protein, at 2,534,470 to 2,535,552 Rv2262c Position (kb) 2533 2534Strain fitness (log2 ratio) -1 0 1 2at 2532.374 kb on - strand, within Rv2259at 2532.386 kb on + strand, within Rv2259at 2532.413 kb on + strand, within Rv2259at 2532.413 kb on + strand, within Rv2259at 2532.451 kb on - strand, within Rv2259at 2532.472 kb on - strand, within Rv2259at 2533.209 kb on - strand, within Rv2259at 2533.305 kb on + strandat 2533.305 kb on + strandat 2533.306 kb on - strandat 2533.868 kb on + strand, within Rv2260at 2534.011 kb on + strandat 2534.012 kb on - strandat 2534.243 kb on - strand, within Rv2261cat 2534.377 kb on - strand, within Rv2261cat 2534.571 kb on - strandat 2534.571 kb on - strandat 2534.603 kb on + strand, within Rv2262cat 2534.603 kb on + strand, within Rv2262cat 2534.648 kb on + strand, within Rv2262cat 2534.649 kb on - strand, within Rv2262cat 2534.649 kb on - strand, within Rv2262cat 2534.875 kb on + strand, within Rv2262cat 2534.927 kb on + strand, within Rv2262cat 2534.928 kb on - strand, within Rv2262c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Cumene hydroperoxide 0.05 mM
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2,532,374 - Rv2259 0.12 +1.8
2,532,386 + Rv2259 0.13 +2.0
2,532,413 + Rv2259 0.15 -0.8
2,532,413 + Rv2259 0.15 +0.6
2,532,451 - Rv2259 0.19 -1.1
2,532,472 - Rv2259 0.21 -0.2
2,533,209 - Rv2259 0.89 -1.1
2,533,305 + -0.2
2,533,305 + -0.8
2,533,306 - -0.0
2,533,868 + Rv2260 0.85 +0.8
2,534,011 + -0.2
2,534,012 - -1.3
2,534,243 - Rv2261c 0.48 -0.1
2,534,377 - Rv2261c 0.79 -0.2
2,534,571 - +0.1
2,534,571 - +0.2
2,534,603 + Rv2262c 0.12 +0.6
2,534,603 + Rv2262c 0.12 +0.1
2,534,648 + Rv2262c 0.16 +0.7
2,534,649 - Rv2262c 0.17 -0.6
2,534,649 - Rv2262c 0.17 -0.9
2,534,875 + Rv2262c 0.37 -0.5
2,534,927 + Rv2262c 0.42 -1.5
2,534,928 - Rv2262c 0.42 -0.1

Or see this region's nucleotide sequence