Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0644c

Experiment: 7H9 with Cumene hydroperoxide 0.05 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0643c and Rv0644c are separated by 147 nucleotidesRv0644c and Rv0645c are separated by 166 nucleotides Rv0643c: Rv0643c - Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase), at 737,268 to 738,149 Rv0643c Rv0644c: Rv0644c - Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase), at 738,297 to 739,160 Rv0644c Rv0645c: Rv0645c - Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase), at 739,327 to 740,187 Rv0645c Position (kb) 738 739 740Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3at 737.302 kb on + strandat 737.302 kb on + strandat 737.339 kb on - strandat 737.339 kb on - strandat 737.348 kb on - strandat 737.356 kb on + strandat 737.356 kb on + strandat 737.358 kb on + strand, within Rv0643cat 737.586 kb on + strand, within Rv0643cat 737.586 kb on + strand, within Rv0643cat 737.610 kb on + strand, within Rv0643cat 737.610 kb on + strand, within Rv0643cat 737.611 kb on - strand, within Rv0643cat 737.730 kb on + strand, within Rv0643cat 737.876 kb on - strand, within Rv0643cat 737.876 kb on - strand, within Rv0643cat 737.967 kb on + strand, within Rv0643cat 737.967 kb on + strand, within Rv0643cat 737.968 kb on - strand, within Rv0643cat 738.023 kb on - strand, within Rv0643cat 738.034 kb on + strand, within Rv0643cat 738.034 kb on + strand, within Rv0643cat 738.034 kb on + strand, within Rv0643cat 738.034 kb on + strand, within Rv0643cat 738.085 kb on + strandat 738.202 kb on + strandat 738.203 kb on - strandat 738.274 kb on + strandat 738.275 kb on - strandat 738.298 kb on + strandat 738.376 kb on + strandat 738.377 kb on - strandat 738.385 kb on + strand, within Rv0644cat 738.467 kb on - strand, within Rv0644cat 738.904 kb on + strand, within Rv0644cat 738.904 kb on + strand, within Rv0644cat 738.904 kb on + strand, within Rv0644cat 738.904 kb on + strand, within Rv0644cat 738.904 kb on + strand, within Rv0644cat 738.905 kb on - strand, within Rv0644cat 738.905 kb on - strand, within Rv0644cat 738.981 kb on + strand, within Rv0644cat 738.981 kb on + strand, within Rv0644cat 738.981 kb on + strand, within Rv0644cat 738.981 kb on + strand, within Rv0644cat 738.981 kb on + strand, within Rv0644cat 738.981 kb on + strand, within Rv0644cat 738.981 kb on + strand, within Rv0644cat 738.982 kb on - strand, within Rv0644cat 738.982 kb on - strand, within Rv0644cat 739.063 kb on + strand, within Rv0644cat 739.064 kb on - strand, within Rv0644cat 739.114 kb on + strandat 739.114 kb on + strandat 739.147 kb on - strandat 739.147 kb on - strandat 739.167 kb on + strandat 739.167 kb on + strandat 739.168 kb on - strandat 739.168 kb on - strandat 739.168 kb on - strandat 739.254 kb on - strandat 739.314 kb on - strandat 739.329 kb on - strandat 739.360 kb on + strandat 739.360 kb on + strandat 739.361 kb on - strandat 739.398 kb on - strandat 739.398 kb on - strandat 739.398 kb on - strandat 739.415 kb on + strand, within Rv0645cat 739.415 kb on + strand, within Rv0645cat 739.416 kb on - strand, within Rv0645cat 739.416 kb on - strand, within Rv0645cat 739.462 kb on + strand, within Rv0645cat 739.462 kb on + strand, within Rv0645cat 739.462 kb on + strand, within Rv0645cat 739.496 kb on + strand, within Rv0645cat 739.496 kb on + strand, within Rv0645cat 739.497 kb on - strand, within Rv0645cat 739.676 kb on + strand, within Rv0645cat 739.696 kb on + strand, within Rv0645cat 739.696 kb on + strand, within Rv0645cat 739.696 kb on + strand, within Rv0645cat 739.696 kb on + strand, within Rv0645cat 739.697 kb on - strand, within Rv0645cat 739.728 kb on - strand, within Rv0645cat 739.751 kb on + strand, within Rv0645cat 739.752 kb on - strand, within Rv0645cat 739.752 kb on - strand, within Rv0645cat 739.892 kb on + strand, within Rv0645cat 739.934 kb on + strand, within Rv0645cat 739.935 kb on - strand, within Rv0645cat 740.065 kb on - strand, within Rv0645cat 740.065 kb on - strand, within Rv0645cat 740.094 kb on - strand, within Rv0645cat 740.145 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Cumene hydroperoxide 0.05 mM
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737,302 + -0.3
737,302 + -1.3
737,339 - +1.0
737,339 - -1.0
737,348 - +0.5
737,356 + -0.7
737,356 + -0.8
737,358 + Rv0643c 0.10 -1.3
737,586 + Rv0643c 0.36 -1.1
737,586 + Rv0643c 0.36 -1.2
737,610 + Rv0643c 0.39 +0.7
737,610 + Rv0643c 0.39 -2.7
737,611 - Rv0643c 0.39 -1.3
737,730 + Rv0643c 0.52 -1.8
737,876 - Rv0643c 0.69 +1.2
737,876 - Rv0643c 0.69 +2.0
737,967 + Rv0643c 0.79 -0.1
737,967 + Rv0643c 0.79 -1.6
737,968 - Rv0643c 0.79 -0.8
738,023 - Rv0643c 0.86 -1.5
738,034 + Rv0643c 0.87 +0.9
738,034 + Rv0643c 0.87 -0.1
738,034 + Rv0643c 0.87 -2.1
738,034 + Rv0643c 0.87 -1.3
738,085 + -0.1
738,202 + +3.6
738,203 - -1.4
738,274 + +0.3
738,275 - -0.3
738,298 + +0.1
738,376 + -0.3
738,377 - +0.2
738,385 + Rv0644c 0.10 -1.1
738,467 - Rv0644c 0.20 -0.2
738,904 + Rv0644c 0.70 +0.0
738,904 + Rv0644c 0.70 +1.3
738,904 + Rv0644c 0.70 -0.8
738,904 + Rv0644c 0.70 -0.2
738,904 + Rv0644c 0.70 -1.5
738,905 - Rv0644c 0.70 +0.4
738,905 - Rv0644c 0.70 -0.2
738,981 + Rv0644c 0.79 -0.6
738,981 + Rv0644c 0.79 +3.0
738,981 + Rv0644c 0.79 +1.0
738,981 + Rv0644c 0.79 +0.6
738,981 + Rv0644c 0.79 -0.2
738,981 + Rv0644c 0.79 -0.6
738,981 + Rv0644c 0.79 -1.0
738,982 - Rv0644c 0.79 +0.9
738,982 - Rv0644c 0.79 -0.5
739,063 + Rv0644c 0.89 -0.9
739,064 - Rv0644c 0.89 +0.2
739,114 + +0.6
739,114 + -0.5
739,147 - -0.6
739,147 - -0.0
739,167 + -0.2
739,167 + +0.7
739,168 - -0.2
739,168 - -0.3
739,168 - -0.2
739,254 - -3.0
739,314 - -0.4
739,329 - -0.7
739,360 + -0.3
739,360 + +1.2
739,361 - -0.1
739,398 - -0.3
739,398 - +0.5
739,398 - +1.4
739,415 + Rv0645c 0.10 +1.5
739,415 + Rv0645c 0.10 -0.1
739,416 - Rv0645c 0.10 -0.4
739,416 - Rv0645c 0.10 +0.7
739,462 + Rv0645c 0.16 -0.4
739,462 + Rv0645c 0.16 -0.6
739,462 + Rv0645c 0.16 -0.1
739,496 + Rv0645c 0.20 -0.6
739,496 + Rv0645c 0.20 -0.3
739,497 - Rv0645c 0.20 -1.1
739,676 + Rv0645c 0.41 -0.1
739,696 + Rv0645c 0.43 +0.2
739,696 + Rv0645c 0.43 -1.1
739,696 + Rv0645c 0.43 -2.0
739,696 + Rv0645c 0.43 -0.8
739,697 - Rv0645c 0.43 -0.6
739,728 - Rv0645c 0.47 +0.5
739,751 + Rv0645c 0.49 +0.1
739,752 - Rv0645c 0.49 +0.7
739,752 - Rv0645c 0.49 -0.6
739,892 + Rv0645c 0.66 -0.1
739,934 + Rv0645c 0.70 -0.2
739,935 - Rv0645c 0.71 +0.8
740,065 - Rv0645c 0.86 -0.2
740,065 - Rv0645c 0.86 -0.9
740,094 - Rv0645c 0.89 -0.1
740,145 - +0.4

Or see this region's nucleotide sequence