Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0117

Experiment: 7H9 with Cumene hydroperoxide 0.05 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0116c and Rv0117 are separated by 177 nucleotidesRv0117 and Rv0118c overlap by 17 nucleotides Rv0116c: Rv0116c - Probable L,D-transpeptidase LdtA, at 140,267 to 141,022 Rv0116c Rv0117: Rv0117 - Oxidative stress response regulatory protein OxyS, at 141,200 to 142,144 Rv0117 Rv0118c: Rv0118c - Probable oxalyl-CoA decarboxylase OxcA, at 142,128 to 143,876 Rv0118c Position (kb) 141 142 143Strain fitness (log2 ratio) -1 0 1 2at 140.213 kb on + strandat 140.214 kb on - strandat 140.238 kb on - strandat 140.314 kb on - strandat 140.345 kb on - strand, within Rv0116cat 140.406 kb on + strand, within Rv0116cat 140.406 kb on + strand, within Rv0116cat 140.406 kb on + strand, within Rv0116cat 140.406 kb on + strand, within Rv0116cat 140.407 kb on - strand, within Rv0116cat 140.423 kb on - strand, within Rv0116cat 140.436 kb on + strand, within Rv0116cat 140.454 kb on + strand, within Rv0116cat 140.455 kb on - strand, within Rv0116cat 140.455 kb on - strand, within Rv0116cat 140.489 kb on - strand, within Rv0116cat 140.537 kb on - strand, within Rv0116cat 140.620 kb on + strand, within Rv0116cat 140.621 kb on - strand, within Rv0116cat 140.721 kb on + strand, within Rv0116cat 140.887 kb on + strand, within Rv0116cat 140.887 kb on + strand, within Rv0116cat 140.948 kb on + strandat 141.003 kb on + strandat 141.004 kb on - strandat 141.160 kb on + strandat 141.222 kb on - strandat 141.275 kb on + strandat 141.370 kb on + strand, within Rv0117at 141.397 kb on - strand, within Rv0117at 141.411 kb on + strand, within Rv0117at 141.684 kb on - strand, within Rv0117at 141.696 kb on - strand, within Rv0117at 141.769 kb on - strand, within Rv0117at 141.936 kb on + strand, within Rv0117at 142.027 kb on + strand, within Rv0117at 142.071 kb on + strandat 142.072 kb on - strandat 143.010 kb on + strand, within Rv0118c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Cumene hydroperoxide 0.05 mM
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140,213 + -0.8
140,214 - -0.1
140,238 - -1.0
140,314 - -1.6
140,345 - Rv0116c 0.10 -0.2
140,406 + Rv0116c 0.18 +2.0
140,406 + Rv0116c 0.18 +1.5
140,406 + Rv0116c 0.18 +0.4
140,406 + Rv0116c 0.18 +0.8
140,407 - Rv0116c 0.19 -0.3
140,423 - Rv0116c 0.21 +0.7
140,436 + Rv0116c 0.22 +0.8
140,454 + Rv0116c 0.25 +0.3
140,455 - Rv0116c 0.25 +0.3
140,455 - Rv0116c 0.25 +0.1
140,489 - Rv0116c 0.29 -0.3
140,537 - Rv0116c 0.36 +0.3
140,620 + Rv0116c 0.47 -1.2
140,621 - Rv0116c 0.47 -1.1
140,721 + Rv0116c 0.60 -0.7
140,887 + Rv0116c 0.82 -0.7
140,887 + Rv0116c 0.82 +2.1
140,948 + -1.0
141,003 + +0.5
141,004 - +1.1
141,160 + -0.9
141,222 - +0.1
141,275 + -0.1
141,370 + Rv0117 0.18 -0.1
141,397 - Rv0117 0.21 -1.5
141,411 + Rv0117 0.22 +1.0
141,684 - Rv0117 0.51 +0.3
141,696 - Rv0117 0.52 +0.5
141,769 - Rv0117 0.60 +0.8
141,936 + Rv0117 0.78 +0.4
142,027 + Rv0117 0.88 -0.3
142,071 + -0.2
142,072 - -0.3
143,010 + Rv0118c 0.50 -1.4

Or see this region's nucleotide sequence