Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1242

Experiment: 7H9 with Sutezolid 0.12 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1240 and Rv1241 are separated by 75 nucleotidesRv1241 and Rv1242 overlap by 4 nucleotidesRv1242 and Rv1243c are separated by 22 nucleotides Rv1240: Rv1240 - Probable malate dehydrogenase Mdh, at 1,383,213 to 1,384,202 Rv1240 Rv1241: Rv1241 - Possible antitoxin VapB33, at 1,384,278 to 1,384,538 Rv1241 Rv1242: Rv1242 - Possible toxin VapC33. Contains PIN domain., at 1,384,535 to 1,384,966 Rv1242 Rv1243c: Rv1243c - PE-PGRS family protein PE_PGRS23, at 1,384,989 to 1,386,677 Rv1243c Position (kb) 1384 1385Strain fitness (log2 ratio) -1 0 1 2 3at 1384.565 kb on + strandat 1384.565 kb on + strandat 1384.740 kb on - strand, within Rv1242at 1384.776 kb on + strand, within Rv1242at 1384.777 kb on - strand, within Rv1242at 1384.964 kb on + strandat 1385.025 kb on - strandat 1385.507 kb on + strand, within Rv1243cat 1385.593 kb on - strand, within Rv1243cat 1385.833 kb on - strand, within Rv1243c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sutezolid 0.12 ug/mL
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1,384,565 + +0.1
1,384,565 + -0.2
1,384,740 - Rv1242 0.47 +3.1
1,384,776 + Rv1242 0.56 -0.2
1,384,777 - Rv1242 0.56 +0.5
1,384,964 + +0.1
1,385,025 - +0.3
1,385,507 + Rv1243c 0.31 +0.3
1,385,593 - Rv1243c 0.36 +0.2
1,385,833 - Rv1243c 0.50 +1.0

Or see this region's nucleotide sequence