Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0569

Experiment: 7H9 with Amikacin di2 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0568 and Rv0569 are separated by 134 nucleotidesRv0569 and Rv0570 are separated by 25 nucleotides Rv0568: Rv0568 - Possible cytochrome P450 135B1 Cyp135B1, at 659,450 to 660,868 Rv0568 Rv0569: Rv0569 - Conserved protein, at 661,003 to 661,269 Rv0569 Rv0570: Rv0570 - Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase), at 661,295 to 663,373 Rv0570 Position (kb) 661 662Strain fitness (log2 ratio) -1 0 1 2at 660.086 kb on + strand, within Rv0568at 660.086 kb on + strand, within Rv0568at 660.087 kb on - strand, within Rv0568at 660.359 kb on + strand, within Rv0568at 660.360 kb on - strand, within Rv0568at 660.407 kb on + strand, within Rv0568at 660.408 kb on - strand, within Rv0568at 660.518 kb on + strand, within Rv0568at 660.519 kb on - strand, within Rv0568at 660.717 kb on + strand, within Rv0568at 660.718 kb on - strand, within Rv0568at 661.049 kb on + strand, within Rv0569at 661.077 kb on + strand, within Rv0569at 661.078 kb on - strand, within Rv0569at 661.111 kb on + strand, within Rv0569at 661.111 kb on + strand, within Rv0569at 661.112 kb on - strand, within Rv0569at 661.267 kb on + strandat 661.267 kb on + strandat 661.267 kb on + strandat 661.544 kb on + strand, within Rv0570at 661.545 kb on - strand, within Rv0570at 661.614 kb on + strand, within Rv0570at 661.614 kb on + strand, within Rv0570at 662.051 kb on + strand, within Rv0570at 662.052 kb on - strand, within Rv0570at 662.244 kb on + strand, within Rv0570

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Amikacin di2 ug/mL
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660,086 + Rv0568 0.45 -0.3
660,086 + Rv0568 0.45 -0.3
660,087 - Rv0568 0.45 +0.4
660,359 + Rv0568 0.64 -0.4
660,360 - Rv0568 0.64 +0.6
660,407 + Rv0568 0.67 -0.1
660,408 - Rv0568 0.68 +0.3
660,518 + Rv0568 0.75 +0.0
660,519 - Rv0568 0.75 +0.6
660,717 + Rv0568 0.89 +0.7
660,718 - Rv0568 0.89 +0.0
661,049 + Rv0569 0.17 +0.6
661,077 + Rv0569 0.28 +0.7
661,078 - Rv0569 0.28 -0.1
661,111 + Rv0569 0.40 +0.9
661,111 + Rv0569 0.40 -0.3
661,112 - Rv0569 0.41 +0.3
661,267 + +0.8
661,267 + -1.3
661,267 + +1.4
661,544 + Rv0570 0.12 -0.7
661,545 - Rv0570 0.12 -0.8
661,614 + Rv0570 0.15 -0.1
661,614 + Rv0570 0.15 -0.7
662,051 + Rv0570 0.36 -1.2
662,052 - Rv0570 0.36 -0.1
662,244 + Rv0570 0.46 +1.9

Or see this region's nucleotide sequence