Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1702c

Experiment: 7H9 with Amikacin di2 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1701 and Rv1702c are separated by 73 nucleotidesRv1702c and Rv1703c are separated by 555 nucleotides Rv1701: Rv1701 - Probable integrase/recombinase, at 1,926,202 to 1,927,137 Rv1701 Rv1702c: Rv1702c - Conserved hypothetical protein, at 1,927,211 to 1,928,575 Rv1702c Rv1703c: Rv1703c - Probable catechol-O-methyltransferase, at 1,929,131 to 1,929,721 Rv1703c Position (kb) 1927 1928 1929Strain fitness (log2 ratio) -1 0 1 2at 1926.664 kb on + strand, within Rv1701at 1926.665 kb on - strand, within Rv1701at 1926.970 kb on - strand, within Rv1701at 1926.970 kb on - strand, within Rv1701at 1927.073 kb on - strandat 1927.135 kb on + strandat 1927.261 kb on - strandat 1927.456 kb on - strand, within Rv1702cat 1927.463 kb on + strand, within Rv1702cat 1927.579 kb on + strand, within Rv1702cat 1927.580 kb on - strand, within Rv1702cat 1927.583 kb on + strand, within Rv1702cat 1927.583 kb on + strand, within Rv1702cat 1927.583 kb on + strand, within Rv1702cat 1927.583 kb on + strand, within Rv1702cat 1927.584 kb on - strand, within Rv1702cat 1927.584 kb on - strand, within Rv1702cat 1927.587 kb on + strand, within Rv1702cat 1927.587 kb on + strand, within Rv1702cat 1928.020 kb on - strand, within Rv1702cat 1928.060 kb on + strand, within Rv1702cat 1928.060 kb on + strand, within Rv1702cat 1928.060 kb on + strand, within Rv1702cat 1928.070 kb on - strand, within Rv1702cat 1928.070 kb on - strand, within Rv1702cat 1928.154 kb on - strand, within Rv1702cat 1928.354 kb on + strand, within Rv1702cat 1928.354 kb on + strand, within Rv1702cat 1928.354 kb on + strand, within Rv1702cat 1928.355 kb on - strand, within Rv1702cat 1928.915 kb on + strandat 1928.915 kb on + strandat 1928.916 kb on - strandat 1929.029 kb on + strandat 1929.029 kb on + strandat 1929.030 kb on - strandat 1929.030 kb on - strandat 1929.141 kb on + strandat 1929.238 kb on + strand, within Rv1703cat 1929.238 kb on + strand, within Rv1703cat 1929.238 kb on + strand, within Rv1703cat 1929.238 kb on + strand, within Rv1703cat 1929.239 kb on - strand, within Rv1703cat 1929.239 kb on - strand, within Rv1703cat 1929.240 kb on + strand, within Rv1703cat 1929.240 kb on + strand, within Rv1703cat 1929.240 kb on + strand, within Rv1703cat 1929.240 kb on + strand, within Rv1703cat 1929.241 kb on - strand, within Rv1703cat 1929.320 kb on + strand, within Rv1703cat 1929.410 kb on + strand, within Rv1703cat 1929.537 kb on + strand, within Rv1703c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Amikacin di2 ug/mL
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1,926,664 + Rv1701 0.49 +0.4
1,926,665 - Rv1701 0.49 +0.0
1,926,970 - Rv1701 0.82 -0.5
1,926,970 - Rv1701 0.82 -1.6
1,927,073 - +0.2
1,927,135 + -0.3
1,927,261 - -0.4
1,927,456 - Rv1702c 0.18 +1.5
1,927,463 + Rv1702c 0.18 +0.1
1,927,579 + Rv1702c 0.27 +0.1
1,927,580 - Rv1702c 0.27 -0.5
1,927,583 + Rv1702c 0.27 -0.3
1,927,583 + Rv1702c 0.27 -0.5
1,927,583 + Rv1702c 0.27 -1.5
1,927,583 + Rv1702c 0.27 -1.3
1,927,584 - Rv1702c 0.27 -1.0
1,927,584 - Rv1702c 0.27 -1.1
1,927,587 + Rv1702c 0.28 -0.4
1,927,587 + Rv1702c 0.28 -0.9
1,928,020 - Rv1702c 0.59 -1.2
1,928,060 + Rv1702c 0.62 -0.7
1,928,060 + Rv1702c 0.62 -0.9
1,928,060 + Rv1702c 0.62 +0.1
1,928,070 - Rv1702c 0.63 -0.4
1,928,070 - Rv1702c 0.63 +0.0
1,928,154 - Rv1702c 0.69 +0.1
1,928,354 + Rv1702c 0.84 -0.6
1,928,354 + Rv1702c 0.84 +1.3
1,928,354 + Rv1702c 0.84 -0.8
1,928,355 - Rv1702c 0.84 +1.9
1,928,915 + +0.3
1,928,915 + -0.4
1,928,916 - -0.3
1,929,029 + -0.6
1,929,029 + +0.3
1,929,030 - -0.4
1,929,030 - -0.5
1,929,141 + +0.0
1,929,238 + Rv1703c 0.18 -0.2
1,929,238 + Rv1703c 0.18 +1.5
1,929,238 + Rv1703c 0.18 +0.5
1,929,238 + Rv1703c 0.18 -0.2
1,929,239 - Rv1703c 0.18 -0.1
1,929,239 - Rv1703c 0.18 -1.1
1,929,240 + Rv1703c 0.18 +0.3
1,929,240 + Rv1703c 0.18 +0.3
1,929,240 + Rv1703c 0.18 +0.3
1,929,240 + Rv1703c 0.18 +0.8
1,929,241 - Rv1703c 0.19 -0.6
1,929,320 + Rv1703c 0.32 -0.3
1,929,410 + Rv1703c 0.47 -0.8
1,929,537 + Rv1703c 0.69 -0.3

Or see this region's nucleotide sequence