Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0503c

Experiment: 7H9 with Clarithromycin 0.967 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0502 and Rv0503c are separated by 3 nucleotidesRv0503c and Rv0504c are separated by 22 nucleotidesRv0504c and Rv0505c are separated by 161 nucleotides Rv0502: Rv0502 - Conserved protein, at 592,791 to 593,867 Rv0502 Rv0503c: Rv0503c - Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase), at 593,871 to 594,779 Rv0503c Rv0504c: Rv0504c - Conserved protein, at 594,802 to 595,302 Rv0504c Rv0505c: Rv0505c - Possible phosphoserine phosphatase SerB1 (PSP) (O-phosphoserine phosphohydrolase) (pspase), at 595,464 to 596,585 Rv0505c Position (kb) 593 594 595Strain fitness (log2 ratio) -2 -1 0 1at 593.089 kb on - strand, within Rv0502at 593.137 kb on + strand, within Rv0502at 593.384 kb on + strand, within Rv0502at 593.384 kb on + strand, within Rv0502at 593.385 kb on - strand, within Rv0502at 593.396 kb on + strand, within Rv0502at 593.397 kb on - strand, within Rv0502at 593.457 kb on + strand, within Rv0502at 593.458 kb on - strand, within Rv0502at 593.524 kb on + strand, within Rv0502at 593.590 kb on - strand, within Rv0502at 593.590 kb on - strand, within Rv0502at 593.652 kb on - strand, within Rv0502at 593.745 kb on + strand, within Rv0502at 593.824 kb on + strandat 593.824 kb on + strandat 593.825 kb on - strandat 593.825 kb on - strandat 593.873 kb on - strandat 593.873 kb on - strandat 593.873 kb on - strandat 593.905 kb on + strandat 593.906 kb on - strandat 593.906 kb on - strandat 593.906 kb on - strandat 593.906 kb on - strandat 593.937 kb on + strandat 593.937 kb on + strandat 593.937 kb on + strandat 593.937 kb on + strandat 593.938 kb on - strandat 593.938 kb on - strandat 593.938 kb on - strandat 593.938 kb on - strandat 593.938 kb on - strandat 593.941 kb on + strandat 593.942 kb on - strandat 593.942 kb on - strandat 593.950 kb on + strandat 593.950 kb on + strandat 593.950 kb on + strandat 593.951 kb on - strandat 593.951 kb on - strandat 593.951 kb on - strandat 593.959 kb on + strandat 593.959 kb on + strandat 593.960 kb on - strandat 594.040 kb on + strand, within Rv0503cat 594.040 kb on + strand, within Rv0503cat 594.040 kb on + strand, within Rv0503cat 594.040 kb on + strand, within Rv0503cat 594.041 kb on - strand, within Rv0503cat 594.041 kb on - strand, within Rv0503cat 594.094 kb on + strand, within Rv0503cat 594.094 kb on + strand, within Rv0503cat 594.094 kb on + strand, within Rv0503cat 594.094 kb on + strand, within Rv0503cat 594.094 kb on + strand, within Rv0503cat 594.095 kb on - strand, within Rv0503cat 594.095 kb on - strand, within Rv0503cat 594.095 kb on - strand, within Rv0503cat 594.097 kb on + strand, within Rv0503cat 594.097 kb on + strand, within Rv0503cat 594.097 kb on + strand, within Rv0503cat 594.097 kb on + strand, within Rv0503cat 594.098 kb on - strand, within Rv0503cat 594.098 kb on - strand, within Rv0503cat 594.098 kb on - strand, within Rv0503cat 594.098 kb on - strand, within Rv0503cat 594.271 kb on + strand, within Rv0503cat 594.272 kb on - strand, within Rv0503cat 594.457 kb on + strand, within Rv0503cat 594.457 kb on + strand, within Rv0503cat 594.499 kb on + strand, within Rv0503cat 594.500 kb on - strand, within Rv0503cat 594.607 kb on + strand, within Rv0503cat 594.608 kb on - strand, within Rv0503cat 594.629 kb on + strand, within Rv0503cat 594.629 kb on + strand, within Rv0503cat 594.630 kb on - strand, within Rv0503cat 594.630 kb on - strand, within Rv0503cat 594.647 kb on - strand, within Rv0503cat 594.658 kb on + strand, within Rv0503cat 594.658 kb on + strand, within Rv0503cat 594.658 kb on + strand, within Rv0503cat 594.659 kb on - strand, within Rv0503cat 594.659 kb on - strand, within Rv0503cat 594.659 kb on - strand, within Rv0503cat 594.659 kb on - strand, within Rv0503cat 594.659 kb on - strand, within Rv0503cat 594.791 kb on + strandat 594.791 kb on + strandat 594.792 kb on - strandat 594.804 kb on - strandat 594.804 kb on - strandat 594.983 kb on + strand, within Rv0504cat 595.175 kb on + strand, within Rv0504cat 595.175 kb on + strand, within Rv0504cat 595.327 kb on - strandat 595.333 kb on + strandat 595.334 kb on - strandat 595.334 kb on - strandat 595.334 kb on - strandat 595.341 kb on - strandat 595.398 kb on + strandat 595.399 kb on - strandat 595.481 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clarithromycin 0.967 ug/mL
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593,089 - Rv0502 0.28 -1.3
593,137 + Rv0502 0.32 -0.9
593,384 + Rv0502 0.55 +0.3
593,384 + Rv0502 0.55 -0.5
593,385 - Rv0502 0.55 +0.6
593,396 + Rv0502 0.56 -0.5
593,397 - Rv0502 0.56 -0.7
593,457 + Rv0502 0.62 -1.5
593,458 - Rv0502 0.62 -0.7
593,524 + Rv0502 0.68 -0.8
593,590 - Rv0502 0.74 -0.3
593,590 - Rv0502 0.74 -0.1
593,652 - Rv0502 0.80 +0.5
593,745 + Rv0502 0.89 -1.2
593,824 + +0.3
593,824 + -0.2
593,825 - -0.1
593,825 - -0.7
593,873 - -0.5
593,873 - -0.2
593,873 - -0.1
593,905 + -0.7
593,906 - -0.9
593,906 - +0.6
593,906 - -1.9
593,906 - -0.1
593,937 + +0.0
593,937 + -0.3
593,937 + -0.2
593,937 + +1.2
593,938 - -0.4
593,938 - +0.1
593,938 - -0.9
593,938 - -0.9
593,938 - -1.0
593,941 + -0.5
593,942 - -0.6
593,942 - +0.5
593,950 + -0.6
593,950 + -0.3
593,950 + -0.7
593,951 - +0.2
593,951 - +0.1
593,951 - +0.4
593,959 + -0.1
593,959 + +0.8
593,960 - -1.4
594,040 + Rv0503c 0.19 -0.0
594,040 + Rv0503c 0.19 -0.0
594,040 + Rv0503c 0.19 -0.9
594,040 + Rv0503c 0.19 -0.3
594,041 - Rv0503c 0.19 -0.2
594,041 - Rv0503c 0.19 -0.7
594,094 + Rv0503c 0.25 -0.9
594,094 + Rv0503c 0.25 +0.3
594,094 + Rv0503c 0.25 -0.2
594,094 + Rv0503c 0.25 +0.0
594,094 + Rv0503c 0.25 -0.2
594,095 - Rv0503c 0.25 -0.1
594,095 - Rv0503c 0.25 -0.3
594,095 - Rv0503c 0.25 -0.5
594,097 + Rv0503c 0.25 -0.4
594,097 + Rv0503c 0.25 +0.9
594,097 + Rv0503c 0.25 -0.6
594,097 + Rv0503c 0.25 +0.9
594,098 - Rv0503c 0.25 +0.4
594,098 - Rv0503c 0.25 -0.0
594,098 - Rv0503c 0.25 -1.4
594,098 - Rv0503c 0.25 -0.8
594,271 + Rv0503c 0.44 -0.7
594,272 - Rv0503c 0.44 -1.1
594,457 + Rv0503c 0.64 -0.1
594,457 + Rv0503c 0.64 -0.8
594,499 + Rv0503c 0.69 +0.5
594,500 - Rv0503c 0.69 +0.1
594,607 + Rv0503c 0.81 -0.2
594,608 - Rv0503c 0.81 +1.0
594,629 + Rv0503c 0.83 -0.5
594,629 + Rv0503c 0.83 +0.4
594,630 - Rv0503c 0.83 +0.3
594,630 - Rv0503c 0.83 -0.5
594,647 - Rv0503c 0.85 -0.2
594,658 + Rv0503c 0.87 +0.1
594,658 + Rv0503c 0.87 +0.1
594,658 + Rv0503c 0.87 -0.2
594,659 - Rv0503c 0.87 -0.3
594,659 - Rv0503c 0.87 -1.3
594,659 - Rv0503c 0.87 -0.5
594,659 - Rv0503c 0.87 -0.2
594,659 - Rv0503c 0.87 -0.2
594,791 + +0.0
594,791 + -0.1
594,792 - -1.7
594,804 - -0.1
594,804 - -0.2
594,983 + Rv0504c 0.36 -2.3
595,175 + Rv0504c 0.74 -0.1
595,175 + Rv0504c 0.74 -2.1
595,327 - +0.7
595,333 + -1.4
595,334 - -0.7
595,334 - -0.3
595,334 - +0.1
595,341 - -0.3
595,398 + -1.2
595,399 - -0.5
595,481 + -1.8

Or see this region's nucleotide sequence