Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3236c

Experiment: 7H9 with Clarithromycin 0.967 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3234c and Rv3235 are separated by 110 nucleotidesRv3235 and Rv3236c are separated by 17 nucleotidesRv3236c and Rv3237c are separated by 4 nucleotidesRv3237c and Rv3238c are separated by 60 nucleotides Rv3234c: Rv3234c - Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3, at 3,610,374 to 3,611,189 Rv3234c Rv3235: Rv3235 - Hypothetical alanine arginine proline rich protein, at 3,611,300 to 3,611,941 Rv3235 Rv3236c: Rv3236c - Probable conserved integral membrane transport protein, at 3,611,959 to 3,613,116 Rv3236c Rv3237c: Rv3237c - Conserved protein, at 3,613,121 to 3,613,603 Rv3237c Rv3238c: Rv3238c - Probable conserved integral membrane protein, at 3,613,664 to 3,614,398 Rv3238c Position (kb) 3611 3612 3613 3614Strain fitness (log2 ratio) -2 -1 0 1 2 3at 3611.122 kb on + strandat 3611.123 kb on - strandat 3611.123 kb on - strandat 3611.123 kb on - strandat 3611.123 kb on - strandat 3611.123 kb on - strandat 3611.123 kb on - strandat 3611.123 kb on - strandat 3611.152 kb on + strandat 3611.404 kb on + strand, within Rv3235at 3611.529 kb on + strand, within Rv3235at 3611.840 kb on + strand, within Rv3235at 3611.840 kb on + strand, within Rv3235at 3611.840 kb on + strand, within Rv3235at 3611.841 kb on - strand, within Rv3235at 3611.841 kb on - strand, within Rv3235at 3611.841 kb on - strand, within Rv3235at 3611.961 kb on - strandat 3611.971 kb on + strandat 3611.972 kb on - strandat 3612.044 kb on + strandat 3612.044 kb on + strandat 3612.045 kb on - strandat 3612.623 kb on + strand, within Rv3236cat 3612.741 kb on - strand, within Rv3236cat 3613.288 kb on + strand, within Rv3237cat 3613.289 kb on - strand, within Rv3237cat 3613.319 kb on - strand, within Rv3237cat 3613.319 kb on - strand, within Rv3237cat 3613.486 kb on - strand, within Rv3237cat 3613.546 kb on - strand, within Rv3237cat 3613.561 kb on - strandat 3613.603 kb on + strandat 3613.603 kb on + strandat 3613.603 kb on + strandat 3613.603 kb on + strandat 3613.636 kb on + strandat 3613.636 kb on + strandat 3613.669 kb on + strandat 3613.669 kb on + strandat 3613.670 kb on - strandat 3613.745 kb on + strand, within Rv3238cat 3613.745 kb on + strand, within Rv3238cat 3613.783 kb on - strand, within Rv3238cat 3613.921 kb on - strand, within Rv3238cat 3613.944 kb on + strand, within Rv3238cat 3613.944 kb on + strand, within Rv3238cat 3613.945 kb on - strand, within Rv3238cat 3613.945 kb on - strand, within Rv3238cat 3613.955 kb on + strand, within Rv3238cat 3613.956 kb on - strand, within Rv3238cat 3614.101 kb on - strand, within Rv3238cat 3614.101 kb on - strand, within Rv3238c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clarithromycin 0.967 ug/mL
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3,611,122 + +1.3
3,611,123 - -0.7
3,611,123 - +0.3
3,611,123 - +0.9
3,611,123 - -0.9
3,611,123 - +0.1
3,611,123 - -0.0
3,611,123 - -0.1
3,611,152 + -0.4
3,611,404 + Rv3235 0.16 -0.7
3,611,529 + Rv3235 0.36 -0.5
3,611,840 + Rv3235 0.84 -1.9
3,611,840 + Rv3235 0.84 +0.4
3,611,840 + Rv3235 0.84 -0.3
3,611,841 - Rv3235 0.84 -0.1
3,611,841 - Rv3235 0.84 -0.5
3,611,841 - Rv3235 0.84 +0.8
3,611,961 - +0.1
3,611,971 + +0.4
3,611,972 - +0.1
3,612,044 + +0.5
3,612,044 + +0.5
3,612,045 - +0.2
3,612,623 + Rv3236c 0.57 -0.2
3,612,741 - Rv3236c 0.68 +1.5
3,613,288 + Rv3237c 0.35 -0.2
3,613,289 - Rv3237c 0.35 -0.7
3,613,319 - Rv3237c 0.41 -0.5
3,613,319 - Rv3237c 0.41 -1.3
3,613,486 - Rv3237c 0.76 -0.5
3,613,546 - Rv3237c 0.88 -2.1
3,613,561 - +0.1
3,613,603 + -0.6
3,613,603 + +0.8
3,613,603 + +0.1
3,613,603 + -0.3
3,613,636 + +0.1
3,613,636 + -0.2
3,613,669 + +0.1
3,613,669 + -0.0
3,613,670 - -0.0
3,613,745 + Rv3238c 0.11 -0.4
3,613,745 + Rv3238c 0.11 -0.1
3,613,783 - Rv3238c 0.16 -0.4
3,613,921 - Rv3238c 0.35 +0.3
3,613,944 + Rv3238c 0.38 +0.3
3,613,944 + Rv3238c 0.38 -0.3
3,613,945 - Rv3238c 0.38 -0.2
3,613,945 - Rv3238c 0.38 +2.9
3,613,955 + Rv3238c 0.40 -0.8
3,613,956 - Rv3238c 0.40 -0.1
3,614,101 - Rv3238c 0.59 -0.5
3,614,101 - Rv3238c 0.59 -0.0

Or see this region's nucleotide sequence