Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2583c

Experiment: 7H9 with Clarithromycin 0.967 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2582 and Rv2583c are separated by 85 nucleotidesRv2583c and Rv2584c are separated by 30 nucleotidesRv2584c and Rv2585c are separated by 103 nucleotides Rv2582: Rv2582 - Probable peptidyl-prolyl cis-trans isomerase B PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl isomerase), at 2,906,814 to 2,907,740 Rv2582 Rv2583c: Rv2583c - Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase), at 2,907,826 to 2,910,198 Rv2583c Rv2584c: Rv2584c - Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase), at 2,910,229 to 2,910,900 Rv2584c Rv2585c: Rv2585c - Possible conserved lipoprotein, at 2,911,004 to 2,912,677 Rv2585c Position (kb) 2907 2908 2909 2910 2911Strain fitness (log2 ratio) -2 -1 0 1 2 3 4at 2907.738 kb on + strandat 2908.093 kb on + strand, within Rv2583cat 2909.295 kb on - strand, within Rv2583cat 2909.295 kb on - strand, within Rv2583cat 2909.391 kb on - strand, within Rv2583cat 2909.442 kb on - strand, within Rv2583cat 2909.780 kb on + strand, within Rv2583cat 2909.885 kb on + strand, within Rv2583cat 2909.886 kb on - strand, within Rv2583cat 2909.975 kb on + strandat 2909.975 kb on + strandat 2909.976 kb on - strandat 2910.458 kb on + strand, within Rv2584cat 2910.467 kb on + strand, within Rv2584cat 2910.471 kb on - strand, within Rv2584cat 2910.748 kb on + strand, within Rv2584cat 2910.749 kb on - strand, within Rv2584cat 2910.749 kb on - strand, within Rv2584cat 2910.749 kb on - strand, within Rv2584cat 2910.749 kb on - strand, within Rv2584cat 2910.835 kb on + strandat 2910.835 kb on + strandat 2910.870 kb on - strandat 2910.885 kb on + strandat 2910.885 kb on + strandat 2910.885 kb on + strandat 2910.885 kb on + strandat 2910.936 kb on + strandat 2910.936 kb on + strandat 2910.946 kb on + strandat 2910.946 kb on + strandat 2910.946 kb on + strandat 2910.947 kb on - strandat 2911.114 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clarithromycin 0.967 ug/mL
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2,907,738 + -0.2
2,908,093 + Rv2583c 0.11 -2.5
2,909,295 - Rv2583c 0.62 +1.3
2,909,295 - Rv2583c 0.62 +0.8
2,909,391 - Rv2583c 0.66 +3.2
2,909,442 - Rv2583c 0.68 +1.9
2,909,780 + Rv2583c 0.82 +2.2
2,909,885 + Rv2583c 0.87 +3.4
2,909,886 - Rv2583c 0.87 +4.5
2,909,975 + +2.8
2,909,975 + +1.3
2,909,976 - +1.1
2,910,458 + Rv2584c 0.34 -0.5
2,910,467 + Rv2584c 0.35 -0.6
2,910,471 - Rv2584c 0.36 +0.0
2,910,748 + Rv2584c 0.77 -0.7
2,910,749 - Rv2584c 0.77 -0.1
2,910,749 - Rv2584c 0.77 +0.0
2,910,749 - Rv2584c 0.77 -0.3
2,910,749 - Rv2584c 0.77 -0.5
2,910,835 + +0.3
2,910,835 + +0.2
2,910,870 - +0.7
2,910,885 + +0.1
2,910,885 + +0.3
2,910,885 + +0.2
2,910,885 + -0.6
2,910,936 + +0.2
2,910,936 + -0.8
2,910,946 + -0.4
2,910,946 + -0.3
2,910,946 + +2.1
2,910,947 - +0.2
2,911,114 - +0.4

Or see this region's nucleotide sequence