Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2348c

Experiment: 7H9 with Clarithromycin 0.967 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2345 and Rv2346c are separated by 84 nucleotidesRv2346c and Rv2347c are separated by 50 nucleotidesRv2347c and Rv2348c are separated by 134 nucleotidesRv2348c and Rv2349c are separated by 191 nucleotides Rv2345: Rv2345 - Possible conserved transmembrane protein, at 2,623,821 to 2,625,803 Rv2345 Rv2346c: Rv2346c - Putative ESAT-6 like protein EsxO (ESAT-6 like protein 6), at 2,625,888 to 2,626,172 Rv2346c Rv2347c: Rv2347c - Putative ESAT-6 like protein EsxP (ESAT-6 like protein 7), at 2,626,223 to 2,626,519 Rv2347c Rv2348c: Rv2348c - Hypothetical protein, at 2,626,654 to 2,626,980 Rv2348c Rv2349c: Rv2349c - Probable phospholipase C 3 PlcC, at 2,627,172 to 2,628,698 Rv2349c Position (kb) 2626 2627Strain fitness (log2 ratio) -1 0 1 2at 2625.686 kb on + strandat 2625.687 kb on - strandat 2625.801 kb on + strandat 2625.801 kb on + strandat 2625.802 kb on - strandat 2625.832 kb on + strandat 2625.832 kb on + strandat 2625.833 kb on - strandat 2626.160 kb on - strandat 2626.160 kb on - strandat 2626.856 kb on + strand, within Rv2348cat 2627.058 kb on + strandat 2627.058 kb on + strandat 2627.058 kb on + strandat 2627.059 kb on - strandat 2627.059 kb on - strandat 2627.059 kb on - strandat 2627.077 kb on + strandat 2627.078 kb on - strandat 2627.152 kb on + strandat 2627.152 kb on + strandat 2627.152 kb on + strandat 2627.153 kb on - strandat 2627.153 kb on - strandat 2627.384 kb on + strand, within Rv2349cat 2627.385 kb on - strand, within Rv2349cat 2627.385 kb on - strand, within Rv2349cat 2627.509 kb on + strand, within Rv2349cat 2627.562 kb on + strand, within Rv2349cat 2627.563 kb on - strand, within Rv2349cat 2627.681 kb on - strand, within Rv2349cat 2627.736 kb on + strand, within Rv2349cat 2627.869 kb on + strand, within Rv2349cat 2627.888 kb on - strand, within Rv2349cat 2627.945 kb on + strand, within Rv2349c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clarithromycin 0.967 ug/mL
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2,625,686 + +0.6
2,625,687 - -0.6
2,625,801 + -1.0
2,625,801 + +0.4
2,625,802 - -0.7
2,625,832 + -0.4
2,625,832 + +0.0
2,625,833 - -0.0
2,626,160 - +0.1
2,626,160 - +1.9
2,626,856 + Rv2348c 0.62 +0.6
2,627,058 + -0.1
2,627,058 + -0.1
2,627,058 + -0.5
2,627,059 - -0.3
2,627,059 - -0.5
2,627,059 - -0.9
2,627,077 + -0.0
2,627,078 - -0.3
2,627,152 + +0.0
2,627,152 + -0.0
2,627,152 + +0.2
2,627,153 - -0.2
2,627,153 - -0.6
2,627,384 + Rv2349c 0.14 +0.9
2,627,385 - Rv2349c 0.14 -0.4
2,627,385 - Rv2349c 0.14 +0.2
2,627,509 + Rv2349c 0.22 +0.4
2,627,562 + Rv2349c 0.26 +0.7
2,627,563 - Rv2349c 0.26 +0.5
2,627,681 - Rv2349c 0.33 -0.2
2,627,736 + Rv2349c 0.37 -0.7
2,627,869 + Rv2349c 0.46 -0.9
2,627,888 - Rv2349c 0.47 +0.0
2,627,945 + Rv2349c 0.51 -0.7

Or see this region's nucleotide sequence