Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1884c

Experiment: 7H9 with Clarithromycin 0.967 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1882c and Rv1883c are separated by 27 nucleotidesRv1883c and Rv1884c are separated by 38 nucleotidesRv1884c and Rv1885c are separated by 11 nucleotidesRv1885c and Rv1886c are separated by 17 nucleotides Rv1882c: Rv1882c - Probable short-chain type dehydrogenase/reductase, at 2,132,370 to 2,133,203 Rv1882c Rv1883c: Rv1883c - Conserved hypothetical protein, at 2,133,231 to 2,133,692 Rv1883c Rv1884c: Rv1884c - Probable resuscitation-promoting factor RpfC, at 2,133,731 to 2,134,261 Rv1884c Rv1885c: Rv1885c - Chorismate mutase, at 2,134,273 to 2,134,872 Rv1885c Rv1886c: Rv1886c - Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen), at 2,134,890 to 2,135,867 Rv1886c Position (kb) 2133 2134 2135Strain fitness (log2 ratio) -2 -1 0 1at 2132.755 kb on + strand, within Rv1882cat 2132.766 kb on - strand, within Rv1882cat 2132.779 kb on + strand, within Rv1882cat 2132.779 kb on + strand, within Rv1882cat 2132.779 kb on + strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.836 kb on + strand, within Rv1882cat 2132.836 kb on + strand, within Rv1882cat 2132.836 kb on + strand, within Rv1882cat 2132.837 kb on - strand, within Rv1882cat 2132.837 kb on - strand, within Rv1882cat 2132.851 kb on + strand, within Rv1882cat 2133.075 kb on + strand, within Rv1882cat 2133.076 kb on - strand, within Rv1882cat 2133.112 kb on - strand, within Rv1882cat 2133.120 kb on + strandat 2133.120 kb on + strandat 2133.120 kb on + strandat 2133.120 kb on + strandat 2133.121 kb on - strandat 2133.325 kb on + strand, within Rv1883cat 2133.325 kb on + strand, within Rv1883cat 2133.325 kb on + strand, within Rv1883cat 2133.326 kb on - strand, within Rv1883cat 2133.326 kb on - strand, within Rv1883cat 2133.328 kb on + strand, within Rv1883cat 2133.329 kb on - strand, within Rv1883cat 2133.329 kb on - strand, within Rv1883cat 2133.406 kb on + strand, within Rv1883cat 2133.474 kb on + strand, within Rv1883cat 2133.474 kb on + strand, within Rv1883cat 2133.692 kb on + strandat 2133.692 kb on + strandat 2133.693 kb on - strandat 2133.693 kb on - strandat 2133.708 kb on + strandat 2134.193 kb on + strand, within Rv1884cat 2134.298 kb on + strandat 2134.339 kb on - strand, within Rv1885cat 2134.449 kb on + strand, within Rv1885cat 2134.483 kb on + strand, within Rv1885cat 2134.483 kb on + strand, within Rv1885cat 2134.484 kb on - strand, within Rv1885cat 2134.544 kb on + strand, within Rv1885cat 2134.596 kb on - strand, within Rv1885cat 2134.796 kb on - strand, within Rv1885cat 2134.847 kb on + strandat 2134.849 kb on + strandat 2134.849 kb on + strandat 2134.849 kb on + strandat 2134.850 kb on - strandat 2134.850 kb on - strandat 2134.850 kb on - strandat 2134.850 kb on - strandat 2134.850 kb on - strandat 2134.850 kb on - strandat 2134.952 kb on - strandat 2135.017 kb on + strand, within Rv1886cat 2135.017 kb on + strand, within Rv1886cat 2135.017 kb on + strand, within Rv1886cat 2135.017 kb on + strand, within Rv1886cat 2135.017 kb on + strand, within Rv1886cat 2135.018 kb on - strand, within Rv1886cat 2135.018 kb on - strand, within Rv1886cat 2135.018 kb on - strand, within Rv1886cat 2135.018 kb on - strand, within Rv1886cat 2135.076 kb on + strand, within Rv1886cat 2135.076 kb on + strand, within Rv1886cat 2135.076 kb on + strand, within Rv1886cat 2135.077 kb on - strand, within Rv1886cat 2135.077 kb on - strand, within Rv1886cat 2135.077 kb on - strand, within Rv1886cat 2135.168 kb on + strand, within Rv1886cat 2135.169 kb on - strand, within Rv1886c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clarithromycin 0.967 ug/mL
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2,132,755 + Rv1882c 0.46 +0.5
2,132,766 - Rv1882c 0.47 -0.1
2,132,779 + Rv1882c 0.49 -0.0
2,132,779 + Rv1882c 0.49 -0.2
2,132,779 + Rv1882c 0.49 -1.9
2,132,780 - Rv1882c 0.49 +0.2
2,132,780 - Rv1882c 0.49 -0.0
2,132,780 - Rv1882c 0.49 +0.3
2,132,780 - Rv1882c 0.49 -0.9
2,132,780 - Rv1882c 0.49 +0.3
2,132,836 + Rv1882c 0.56 -0.7
2,132,836 + Rv1882c 0.56 -0.1
2,132,836 + Rv1882c 0.56 -0.1
2,132,837 - Rv1882c 0.56 -2.0
2,132,837 - Rv1882c 0.56 +0.5
2,132,851 + Rv1882c 0.58 -0.5
2,133,075 + Rv1882c 0.85 +0.5
2,133,076 - Rv1882c 0.85 +1.5
2,133,112 - Rv1882c 0.89 -0.1
2,133,120 + -0.1
2,133,120 + +1.6
2,133,120 + -0.3
2,133,120 + +0.2
2,133,121 - +0.7
2,133,325 + Rv1883c 0.20 -0.0
2,133,325 + Rv1883c 0.20 -0.4
2,133,325 + Rv1883c 0.20 -0.1
2,133,326 - Rv1883c 0.21 +0.2
2,133,326 - Rv1883c 0.21 -0.4
2,133,328 + Rv1883c 0.21 -0.2
2,133,329 - Rv1883c 0.21 -0.6
2,133,329 - Rv1883c 0.21 -1.0
2,133,406 + Rv1883c 0.38 -0.3
2,133,474 + Rv1883c 0.53 -0.0
2,133,474 + Rv1883c 0.53 -0.3
2,133,692 + -0.0
2,133,692 + -0.2
2,133,693 - -0.6
2,133,693 - +0.3
2,133,708 + -0.4
2,134,193 + Rv1884c 0.87 +0.3
2,134,298 + -0.5
2,134,339 - Rv1885c 0.11 -0.4
2,134,449 + Rv1885c 0.29 -0.7
2,134,483 + Rv1885c 0.35 -0.5
2,134,483 + Rv1885c 0.35 -0.5
2,134,484 - Rv1885c 0.35 -0.3
2,134,544 + Rv1885c 0.45 -0.0
2,134,596 - Rv1885c 0.54 -0.2
2,134,796 - Rv1885c 0.87 +1.0
2,134,847 + +1.7
2,134,849 + -0.7
2,134,849 + -0.6
2,134,849 + -0.7
2,134,850 - +1.1
2,134,850 - +0.7
2,134,850 - -0.2
2,134,850 - -0.0
2,134,850 - -2.5
2,134,850 - -0.2
2,134,952 - -0.2
2,135,017 + Rv1886c 0.13 -0.9
2,135,017 + Rv1886c 0.13 -0.7
2,135,017 + Rv1886c 0.13 -0.4
2,135,017 + Rv1886c 0.13 -0.6
2,135,017 + Rv1886c 0.13 -0.6
2,135,018 - Rv1886c 0.13 -0.9
2,135,018 - Rv1886c 0.13 -0.4
2,135,018 - Rv1886c 0.13 -0.8
2,135,018 - Rv1886c 0.13 -0.6
2,135,076 + Rv1886c 0.19 -1.1
2,135,076 + Rv1886c 0.19 -0.9
2,135,076 + Rv1886c 0.19 -0.0
2,135,077 - Rv1886c 0.19 -0.3
2,135,077 - Rv1886c 0.19 -0.7
2,135,077 - Rv1886c 0.19 -1.4
2,135,168 + Rv1886c 0.28 -0.5
2,135,169 - Rv1886c 0.29 -0.8

Or see this region's nucleotide sequence