Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1773c

Experiment: 7H9 with Clarithromycin 0.967 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1771 and Rv1772 are separated by 188 nucleotidesRv1772 and Rv1773c are separated by 72 nucleotidesRv1773c and Rv1774 are separated by 65 nucleotides Rv1771: Rv1771 - L-gulono-1,4-lactone dehydrogenase, at 2,005,161 to 2,006,447 Rv1771 Rv1772: Rv1772 - Hypothetical protein, at 2,006,636 to 2,006,947 Rv1772 Rv1773c: Rv1773c - Probable transcriptional regulatory protein, at 2,007,020 to 2,007,766 Rv1773c Rv1774: Rv1774 - Probable oxidoreductase, at 2,007,832 to 2,009,172 Rv1774 Position (kb) 2007 2008Strain fitness (log2 ratio) -1 0 1at 2006.197 kb on - strand, within Rv1771at 2006.215 kb on - strand, within Rv1771at 2006.233 kb on - strand, within Rv1771at 2006.256 kb on + strand, within Rv1771at 2006.257 kb on - strand, within Rv1771at 2006.313 kb on - strand, within Rv1771at 2006.523 kb on + strandat 2006.531 kb on - strandat 2006.946 kb on - strandat 2007.425 kb on + strand, within Rv1773cat 2007.498 kb on - strand, within Rv1773cat 2007.653 kb on + strand, within Rv1773cat 2007.653 kb on + strand, within Rv1773cat 2007.680 kb on + strand, within Rv1773cat 2007.757 kb on + strandat 2007.758 kb on - strandat 2007.778 kb on - strandat 2007.831 kb on + strandat 2007.831 kb on + strandat 2007.831 kb on + strandat 2007.831 kb on + strandat 2007.831 kb on + strandat 2008.009 kb on - strand, within Rv1774at 2008.417 kb on + strand, within Rv1774at 2008.417 kb on + strand, within Rv1774at 2008.462 kb on + strand, within Rv1774at 2008.462 kb on + strand, within Rv1774at 2008.706 kb on - strand, within Rv1774at 2008.706 kb on - strand, within Rv1774at 2008.708 kb on - strand, within Rv1774at 2008.754 kb on - strand, within Rv1774

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clarithromycin 0.967 ug/mL
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2,006,197 - Rv1771 0.80 -0.4
2,006,215 - Rv1771 0.82 -0.2
2,006,233 - Rv1771 0.83 +0.6
2,006,256 + Rv1771 0.85 -0.0
2,006,257 - Rv1771 0.85 -0.5
2,006,313 - Rv1771 0.90 -0.1
2,006,523 + -0.1
2,006,531 - +0.1
2,006,946 - +0.9
2,007,425 + Rv1773c 0.54 +0.9
2,007,498 - Rv1773c 0.64 +1.3
2,007,653 + Rv1773c 0.85 +0.6
2,007,653 + Rv1773c 0.85 +0.3
2,007,680 + Rv1773c 0.88 -0.7
2,007,757 + -0.5
2,007,758 - -0.3
2,007,778 - +0.3
2,007,831 + -1.0
2,007,831 + -0.2
2,007,831 + -0.7
2,007,831 + -0.7
2,007,831 + -0.3
2,008,009 - Rv1774 0.13 -0.2
2,008,417 + Rv1774 0.44 +0.9
2,008,417 + Rv1774 0.44 +0.1
2,008,462 + Rv1774 0.47 +0.2
2,008,462 + Rv1774 0.47 +0.2
2,008,706 - Rv1774 0.65 -0.4
2,008,706 - Rv1774 0.65 +0.1
2,008,708 - Rv1774 0.65 +0.0
2,008,754 - Rv1774 0.69 +0.1

Or see this region's nucleotide sequence