Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1444c

Experiment: 7H9 with Clarithromycin 0.967 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1443c and Rv1444c are separated by 594 nucleotidesRv1444c and Rv1445c are separated by 16 nucleotidesRv1445c and Rv1446c overlap by 4 nucleotides Rv1443c: Rv1443c - Unknown protein, at 1,622,207 to 1,622,692 Rv1443c Rv1444c: Rv1444c - Unknown protein, at 1,623,287 to 1,623,697 Rv1444c Rv1445c: Rv1445c - Probable 6-phosphogluconolactonase DevB (6PGL), at 1,623,714 to 1,624,457 Rv1445c Rv1446c: Rv1446c - Putative OXPP cycle protein OpcA, at 1,624,454 to 1,625,365 Rv1446c Position (kb) 1623 1624Strain fitness (log2 ratio) -1 0 1 2at 1622.708 kb on + strandat 1622.736 kb on - strandat 1622.736 kb on - strandat 1622.932 kb on - strandat 1623.126 kb on - strandat 1623.158 kb on - strandat 1623.399 kb on + strand, within Rv1444cat 1623.400 kb on - strand, within Rv1444cat 1623.481 kb on + strand, within Rv1444cat 1623.482 kb on - strand, within Rv1444cat 1624.237 kb on + strand, within Rv1445cat 1624.449 kb on - strandat 1624.449 kb on - strandat 1624.449 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clarithromycin 0.967 ug/mL
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1,622,708 + -0.2
1,622,736 - -0.2
1,622,736 - -0.2
1,622,932 - -0.7
1,623,126 - -0.3
1,623,158 - -0.9
1,623,399 + Rv1444c 0.27 +2.5
1,623,400 - Rv1444c 0.27 +0.6
1,623,481 + Rv1444c 0.47 +0.1
1,623,482 - Rv1444c 0.47 +0.6
1,624,237 + Rv1445c 0.70 -1.1
1,624,449 - +0.0
1,624,449 - -0.6
1,624,449 - -0.3

Or see this region's nucleotide sequence