Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1144

Experiment: 7H9 with Clarithromycin 0.967 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Clarithromycin 0.967 ug/mL
1,270,193	+		Rv1143	0.12	-0.3
1,270,194	-		Rv1143	0.12	+0.4
1,270,217	+		Rv1143	0.14	+2.5
1,270,226	+		Rv1143	0.15	+0.2
1,270,383	+		Rv1143	0.30	-1.3
1,270,383	+		Rv1143	0.30	+0.3
1,270,421	+		Rv1143	0.33	+0.3
1,270,449	+		Rv1143	0.36	+1.1
1,270,449	+		Rv1143	0.36	+0.2
1,270,449	+		Rv1143	0.36	+0.1
1,270,450	-		Rv1143	0.36	-0.3
1,270,450	-		Rv1143	0.36	+0.2
1,270,450	-		Rv1143	0.36	-0.1
1,270,729	-		Rv1143	0.62	-0.1
1,270,729	-		Rv1143	0.62	+0.2
1,270,731	+		Rv1143	0.62	+0.1
1,270,731	+		Rv1143	0.62	-0.2
1,270,731	+		Rv1143	0.62	+0.6
1,270,731	+		Rv1143	0.62	-0.2
1,270,731	+		Rv1143	0.62	+0.4
1,270,732	-		Rv1143	0.62	-0.1
1,270,740	+		Rv1143	0.63	-0.4
1,270,740	+		Rv1143	0.63	+0.2
1,270,741	-		Rv1143	0.63	+0.1
1,270,741	-		Rv1143	0.63	+0.4
1,270,762	-		Rv1143	0.65	+0.7
1,270,762	-		Rv1143	0.65	+1.0
1,270,794	+		Rv1143	0.68	+0.1
1,270,794	+		Rv1143	0.68	-2.9
1,270,795	-		Rv1143	0.68	+0.2
1,270,822	+		Rv1143	0.70	-0.2
1,271,019	+		Rv1143	0.88	+1.8
1,271,020	-		Rv1143	0.88	-1.4
1,271,155	+				-0.7
1,271,155	+				-0.2
1,271,155	+				+0.8
1,271,156	-				+1.5
1,271,427	+		Rv1144	0.36	-0.6
1,271,428	-		Rv1144	0.36	-0.5
1,271,428	-		Rv1144	0.36	+0.1
1,271,573	-		Rv1144	0.55	-0.1
1,271,643	+		Rv1144	0.65	+0.1
1,271,644	-		Rv1144	0.65	+1.2
1,271,817	-		Rv1144	0.88	+0.0
1,271,827	-		Rv1144	0.89	-1.1
1,271,858	-				-0.4
1,272,093	+				-1.5
1,272,113	-				-0.1
1,272,179	+				+0.0
1,272,180	-				+0.4
1,272,193	-				+0.2
1,272,200	+				-0.0
1,272,200	+				-1.1
1,272,318	+				+0.2
1,272,318	+				-0.3
1,272,319	-				+0.5
1,272,319	-				-0.3
1,272,319	-				-0.3
1,272,319	-				-0.0
1,272,322	+				+1.2
1,272,322	+				+0.0
1,272,323	-				-0.1
1,272,323	-				+0.4
1,272,347	+				-0.4
1,272,347	+				+0.9
1,272,347	+				-0.1
1,272,348	-				-0.5
1,272,348	-				+0.9
1,272,353	-				+0.6
1,272,353	-				+0.1
1,272,361	+				-0.1
1,272,362	-				+0.5
1,272,362	-				+0.4
1,272,723	+		Rv1145	0.33	-1.0
1,272,723	+		Rv1145	0.33	+0.1
1,272,724	-		Rv1145	0.33	+0.2