Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3397c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3396c and Rv3397c are separated by 11 nucleotidesRv3397c and Rv3398c are separated by 28 nucleotides Rv3396c: Rv3396c - Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase), at 3,812,501 to 3,814,078 Rv3396c Rv3397c: Rv3397c - Probable phytoene synthase PhyA, at 3,814,090 to 3,814,998 Rv3397c Rv3398c: Rv3398c - Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate synthase): dimethylallyltransferase (prenyltransferase) (geranyl-diphosphate synthase) + geranyltranstransferase (farnesyl-diphosphate synthase) (farnesyl-pyrophosphate synthetase) (farnesyl diphosphate synthetase) (FPP synthetase) + farnesyltranstransferase (geranylgeranyl-diphosphate synthase), at 3,815,027 to 3,816,106 Rv3398c Position (kb) 3814 3815Strain fitness (log2 ratio) -1 0 1at 3814.265 kb on + strand, within Rv3397cat 3814.442 kb on - strand, within Rv3397c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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3,814,265 + Rv3397c 0.19 +0.5
3,814,442 - Rv3397c 0.39 -0.1

Or see this region's nucleotide sequence