Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3041c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3039c and Rv3040c are separated by 8 nucleotidesRv3040c and Rv3041c overlap by 4 nucleotidesRv3041c and Rv3042c are separated by 14 nucleotides Rv3039c: Rv3039c - Probable enoyl-CoA hydratase EchA17 (crotonase) (unsatured acyl-CoA hydratase) (enoyl hydrase), at 3,399,419 to 3,400,183 Rv3039c Rv3040c: Rv3040c - Conserved protein, at 3,400,192 to 3,401,058 Rv3040c Rv3041c: Rv3041c - Probable conserved ATP-binding protein ABC transporter, at 3,401,055 to 3,401,918 Rv3041c Rv3042c: Rv3042c - Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase), at 3,401,933 to 3,403,162 Rv3042c Position (kb) 3401 3402Strain fitness (log2 ratio) -1 0 1 2at 3400.344 kb on + strand, within Rv3040cat 3400.345 kb on - strand, within Rv3040cat 3400.493 kb on - strand, within Rv3040cat 3400.512 kb on - strand, within Rv3040cat 3400.512 kb on - strand, within Rv3040cat 3401.105 kb on - strandat 3401.341 kb on - strand, within Rv3041cat 3401.447 kb on - strand, within Rv3041cat 3401.507 kb on - strand, within Rv3041cat 3401.934 kb on + strandat 3401.935 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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3,400,344 + Rv3040c 0.18 +0.2
3,400,345 - Rv3040c 0.18 +0.3
3,400,493 - Rv3040c 0.35 +2.5
3,400,512 - Rv3040c 0.37 -0.3
3,400,512 - Rv3040c 0.37 -0.6
3,401,105 - -0.3
3,401,341 - Rv3041c 0.33 +0.2
3,401,447 - Rv3041c 0.45 -0.1
3,401,507 - Rv3041c 0.52 +0.4
3,401,934 + -0.7
3,401,935 - -0.4

Or see this region's nucleotide sequence