Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3020c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3018c and Rv3018A are separated by 85 nucleotidesRv3018A and Rv3019c are separated by 295 nucleotidesRv3019c and Rv3020c are separated by 34 nucleotidesRv3020c and Rv3021c are separated by 46 nucleotides Rv3018c: Rv3018c - PPE family protein PPE46, at 3,376,939 to 3,378,243 Rv3018c Rv3018A: Rv3018A - PE family protein PE27A, at 3,378,329 to 3,378,415 Rv3018A Rv3019c: Rv3019c - Secreted ESAT-6 like protein EsxR (TB10.3) (ESAT-6 like protein 9), at 3,378,711 to 3,379,001 Rv3019c Rv3020c: Rv3020c - ESAT-6 like protein EsxS, at 3,379,036 to 3,379,329 Rv3020c Rv3021c: Rv3021c - PPE family protein PPE47, at 3,379,376 to 3,380,452 Rv3021c Position (kb) 3379 3380Strain fitness (log2 ratio) -2 -1 0 1at 3378.433 kb on + strandat 3378.482 kb on + strandat 3378.486 kb on + strandat 3378.507 kb on - strandat 3378.817 kb on - strand, within Rv3019cat 3378.850 kb on + strand, within Rv3019cat 3378.850 kb on + strand, within Rv3019cat 3378.851 kb on - strand, within Rv3019cat 3378.851 kb on - strand, within Rv3019cat 3378.851 kb on - strand, within Rv3019cat 3378.986 kb on - strandat 3378.986 kb on - strandat 3378.986 kb on - strandat 3378.986 kb on - strandat 3379.037 kb on + strandat 3379.050 kb on - strandat 3379.082 kb on + strand, within Rv3020cat 3379.083 kb on - strand, within Rv3020cat 3379.132 kb on - strand, within Rv3020cat 3379.248 kb on + strand, within Rv3020cat 3379.269 kb on + strand, within Rv3020cat 3379.893 kb on - strand, within Rv3021c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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3,378,433 + +0.7
3,378,482 + +0.9
3,378,486 + -2.1
3,378,507 - -0.5
3,378,817 - Rv3019c 0.36 -0.4
3,378,850 + Rv3019c 0.48 -0.0
3,378,850 + Rv3019c 0.48 -0.1
3,378,851 - Rv3019c 0.48 +1.6
3,378,851 - Rv3019c 0.48 +1.3
3,378,851 - Rv3019c 0.48 -0.1
3,378,986 - -0.6
3,378,986 - -0.3
3,378,986 - -0.3
3,378,986 - -0.2
3,379,037 + -0.5
3,379,050 - -0.4
3,379,082 + Rv3020c 0.16 +0.7
3,379,083 - Rv3020c 0.16 -0.2
3,379,132 - Rv3020c 0.33 +0.9
3,379,248 + Rv3020c 0.72 +1.1
3,379,269 + Rv3020c 0.79 -0.2
3,379,893 - Rv3021c 0.48 +0.9

Or see this region's nucleotide sequence