Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2586c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2585c and Rv2586c are separated by 5 nucleotidesRv2586c and Rv2587c are separated by 3 nucleotides Rv2585c: Rv2585c - Possible conserved lipoprotein, at 2,911,004 to 2,912,677 Rv2585c Rv2586c: Rv2586c - Probable protein-export membrane protein SecF, at 2,912,683 to 2,914,011 Rv2586c Rv2587c: Rv2587c - Probable protein-export membrane protein SecD, at 2,914,015 to 2,915,736 Rv2587c Position (kb) 2912 2913 2914 2915Strain fitness (log2 ratio) -1 0 1at 2911.765 kb on - strand, within Rv2585cat 2911.962 kb on + strand, within Rv2585cat 2912.079 kb on - strand, within Rv2585cat 2912.260 kb on + strand, within Rv2585cat 2912.261 kb on - strand, within Rv2585cat 2912.310 kb on - strand, within Rv2585cat 2912.518 kb on + strandat 2912.529 kb on + strandat 2912.529 kb on + strandat 2912.530 kb on - strandat 2912.530 kb on - strandat 2912.557 kb on - strandat 2912.654 kb on - strandat 2912.654 kb on - strandat 2912.685 kb on - strandat 2912.902 kb on - strand, within Rv2586c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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2,911,765 - Rv2585c 0.45 +1.0
2,911,962 + Rv2585c 0.57 -0.3
2,912,079 - Rv2585c 0.64 +0.5
2,912,260 + Rv2585c 0.75 -1.0
2,912,261 - Rv2585c 0.75 +0.6
2,912,310 - Rv2585c 0.78 -0.2
2,912,518 + -0.1
2,912,529 + -1.0
2,912,529 + -0.4
2,912,530 - +1.0
2,912,530 - +1.5
2,912,557 - -0.1
2,912,654 - -0.0
2,912,654 - -0.6
2,912,685 - -0.2
2,912,902 - Rv2586c 0.16 +0.2

Or see this region's nucleotide sequence