Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2289

Experiment: 7H9 with Delamanid 0.236 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Delamanid 0.236 ug/mL
2,560,691	+		Rv2287	0.61	-0.1
2,561,098	+		Rv2287	0.86	+0.0
2,561,193	-				+0.1
2,561,292	-				+0.7
2,561,703	+				+0.1
2,561,704	-				+0.9
2,561,715	+				+0.4
2,561,716	-				-0.5
2,561,727	+				-1.3
2,561,727	+				+0.5
2,561,727	+				-0.2
2,561,727	+				+0.6
2,561,849	-		Rv2289	0.22	-0.5
2,561,903	+		Rv2289	0.29	-0.4
2,562,076	-		Rv2289	0.51	+0.3
2,562,076	-		Rv2289	0.51	-0.6
2,562,076	-		Rv2289	0.51	+2.5
2,562,132	+		Rv2289	0.58	+0.2
2,562,133	-		Rv2289	0.58	-0.2
2,562,178	+		Rv2289	0.64	-0.5
2,562,178	+		Rv2289	0.64	-0.4
2,562,179	-		Rv2289	0.64	+1.0
2,562,188	+		Rv2289	0.66	+0.5
2,562,188	+		Rv2289	0.66	-0.3
2,562,188	+		Rv2289	0.66	-0.8
2,562,189	-		Rv2289	0.66	-0.6
2,562,293	+		Rv2289	0.79	-0.4
2,562,294	-		Rv2289	0.79	-0.2
2,562,294	-		Rv2289	0.79	-1.4
2,562,294	-		Rv2289	0.79	+0.3
2,562,354	+		Rv2289	0.87	-0.2
2,562,459	-				+1.7
2,562,565	+				-0.5
2,562,579	+				-0.3
2,562,753	+		Rv2290	0.30	-0.0
2,562,754	-		Rv2290	0.30	+0.0
2,562,754	-		Rv2290	0.30	+0.7
2,562,754	-		Rv2290	0.30	+2.5
2,562,763	+		Rv2290	0.32	-1.2
2,562,763	+		Rv2290	0.32	+0.6
2,562,763	+		Rv2290	0.32	-0.3
2,562,763	+		Rv2290	0.32	+0.1
2,562,764	-		Rv2290	0.32	+1.2
2,562,764	-		Rv2290	0.32	+0.1
2,562,764	-		Rv2290	0.32	+0.2
2,562,764	-		Rv2290	0.32	-0.4
2,562,764	-		Rv2290	0.32	-0.8
2,562,810	+		Rv2290	0.41	-1.0
2,562,931	+		Rv2290	0.64	+0.2
2,563,112	+				-0.0
2,563,297	+		Rv2291	0.14	+0.4
2,563,301	+		Rv2291	0.15	+1.4
2,563,302	-		Rv2291	0.15	-0.4
2,563,326	-		Rv2291	0.18	-1.1
2,563,326	-		Rv2291	0.18	-0.5
2,563,359	+		Rv2291	0.22	-0.8
2,563,359	+		Rv2291	0.22	-2.0
2,563,360	-		Rv2291	0.22	+0.0
2,563,360	-		Rv2291	0.22	-0.2
2,563,401	+		Rv2291	0.27	-0.4