Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2267c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2266 and Rv2267c are separated by 253 nucleotidesRv2267c and Rv2268c overlap by 4 nucleotides Rv2266: Rv2266 - Probable cytochrome P450 124 Cyp124, at 2,540,104 to 2,541,390 Rv2266 Rv2267c: Rv2267c - Conserved hypothetical protein, at 2,541,644 to 2,542,810 Rv2267c Rv2268c: Rv2268c - Probable cytochrome P450 128 Cyp128, at 2,542,807 to 2,544,276 Rv2268c Position (kb) 2541 2542 2543Strain fitness (log2 ratio) -2 -1 0 1at 2541.052 kb on + strand, within Rv2266at 2541.185 kb on + strand, within Rv2266at 2541.254 kb on + strand, within Rv2266at 2541.378 kb on + strandat 2541.415 kb on - strandat 2541.416 kb on + strandat 2541.416 kb on + strandat 2541.416 kb on + strandat 2541.417 kb on - strandat 2541.417 kb on - strandat 2541.453 kb on + strandat 2541.453 kb on + strandat 2541.454 kb on - strandat 2541.781 kb on - strand, within Rv2267cat 2541.802 kb on - strand, within Rv2267cat 2541.822 kb on + strand, within Rv2267cat 2541.973 kb on - strand, within Rv2267cat 2542.028 kb on + strand, within Rv2267cat 2542.046 kb on - strand, within Rv2267cat 2542.069 kb on - strand, within Rv2267cat 2542.119 kb on - strand, within Rv2267cat 2542.147 kb on + strand, within Rv2267cat 2542.235 kb on + strand, within Rv2267cat 2542.336 kb on + strand, within Rv2267cat 2542.337 kb on - strand, within Rv2267cat 2542.337 kb on - strand, within Rv2267cat 2542.900 kb on + strandat 2543.172 kb on + strand, within Rv2268cat 2543.246 kb on + strand, within Rv2268c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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2,541,052 + Rv2266 0.74 +0.6
2,541,185 + Rv2266 0.84 -0.1
2,541,254 + Rv2266 0.89 +0.2
2,541,378 + -0.3
2,541,415 - +0.0
2,541,416 + -0.3
2,541,416 + +0.1
2,541,416 + -0.1
2,541,417 - +0.3
2,541,417 - +0.9
2,541,453 + -1.8
2,541,453 + -0.6
2,541,454 - -0.0
2,541,781 - Rv2267c 0.12 +1.1
2,541,802 - Rv2267c 0.14 -0.4
2,541,822 + Rv2267c 0.15 +0.2
2,541,973 - Rv2267c 0.28 -0.3
2,542,028 + Rv2267c 0.33 +1.1
2,542,046 - Rv2267c 0.34 -0.2
2,542,069 - Rv2267c 0.36 +1.4
2,542,119 - Rv2267c 0.41 +0.1
2,542,147 + Rv2267c 0.43 -0.3
2,542,235 + Rv2267c 0.51 +0.2
2,542,336 + Rv2267c 0.59 +1.1
2,542,337 - Rv2267c 0.59 -0.2
2,542,337 - Rv2267c 0.59 +0.2
2,542,900 + +0.4
2,543,172 + Rv2268c 0.25 -0.1
2,543,246 + Rv2268c 0.30 -0.1

Or see this region's nucleotide sequence