Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1729c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1727 and Rv1728c are separated by 24 nucleotidesRv1728c and Rv1729c overlap by 4 nucleotidesRv1729c and Rv1730c are separated by 122 nucleotides Rv1727: Rv1727 - Conserved hypothetical protein, at 1,953,270 to 1,953,839 Rv1727 Rv1728c: Rv1728c - Conserved hypothetical protein, at 1,953,864 to 1,954,634 Rv1728c Rv1729c: Rv1729c - Possible S-adenosylmethionine-dependent methyltransferase, at 1,954,631 to 1,955,569 Rv1729c Rv1730c: Rv1730c - Possible penicillin-binding protein, at 1,955,692 to 1,957,245 Rv1730c Position (kb) 1954 1955 1956Strain fitness (log2 ratio) -1 0 1at 1953.656 kb on - strand, within Rv1727at 1953.779 kb on - strand, within Rv1727at 1953.879 kb on - strandat 1953.898 kb on + strandat 1953.899 kb on - strandat 1954.018 kb on + strand, within Rv1728cat 1954.430 kb on + strand, within Rv1728cat 1954.430 kb on + strand, within Rv1728cat 1954.431 kb on - strand, within Rv1728cat 1954.431 kb on - strand, within Rv1728cat 1954.451 kb on - strand, within Rv1728cat 1954.878 kb on - strand, within Rv1729cat 1955.005 kb on - strand, within Rv1729cat 1955.005 kb on - strand, within Rv1729cat 1955.006 kb on + strand, within Rv1729cat 1955.006 kb on + strand, within Rv1729cat 1955.531 kb on - strandat 1955.693 kb on + strandat 1956.333 kb on + strand, within Rv1730c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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1,953,656 - Rv1727 0.68 -0.5
1,953,779 - Rv1727 0.89 -0.3
1,953,879 - +0.4
1,953,898 + +0.1
1,953,899 - +0.0
1,954,018 + Rv1728c 0.20 -0.3
1,954,430 + Rv1728c 0.73 -0.4
1,954,430 + Rv1728c 0.73 -1.0
1,954,431 - Rv1728c 0.74 -0.8
1,954,431 - Rv1728c 0.74 +0.1
1,954,451 - Rv1728c 0.76 -0.3
1,954,878 - Rv1729c 0.26 -0.6
1,955,005 - Rv1729c 0.40 +0.9
1,955,005 - Rv1729c 0.40 +0.6
1,955,006 + Rv1729c 0.40 +0.4
1,955,006 + Rv1729c 0.40 -0.4
1,955,531 - +0.5
1,955,693 + -0.5
1,956,333 + Rv1730c 0.41 -1.3

Or see this region's nucleotide sequence