Experiment: 7H9 with Delamanid 0.236 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv1415 and Rv1416 overlap by 4 nucleotides Rv1416 and Rv1417 overlap by 4 nucleotides Rv1417 and Rv1418 are separated by 24 nucleotides
Rv1415: Rv1415 - Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase), at 1,590,397 to 1,591,674
Rv1415
Rv1416: Rv1416 - Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase), at 1,591,671 to 1,592,153
Rv1416
Rv1417: Rv1417 - Possible conserved membrane protein, at 1,592,150 to 1,592,614
Rv1417
Rv1418: Rv1418 - Probable lipoprotein LprH, at 1,592,639 to 1,593,325
Rv1418
Position (kb) 1591
1592
1593 Strain fitness (log2 ratio) -1
0
1 at 1592.505 kb on - strand, within Rv1417 at 1592.628 kb on - strand at 1592.876 kb on + strand, within Rv1418 at 1592.876 kb on + strand, within Rv1418 at 1592.975 kb on + strand, within Rv1418 at 1592.976 kb on - strand, within Rv1418 at 1592.978 kb on - strand, within Rv1418 at 1592.978 kb on - strand, within Rv1418
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL remove 1,592,505 - Rv1417 0.76 -0.0 1,592,628 - -0.2 1,592,876 + Rv1418 0.34 -0.6 1,592,876 + Rv1418 0.34 -0.4 1,592,975 + Rv1418 0.49 -0.3 1,592,976 - Rv1418 0.49 +0.2 1,592,978 - Rv1418 0.49 +0.1 1,592,978 - Rv1418 0.49 -0.3
Or see this region's nucleotide sequence