Experiment: 7H9 with Delamanid 0.236 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv1162 and Rv1163 are separated by 56 nucleotides Rv1163 and Rv1164 are separated by 2 nucleotides Rv1164 and Rv1165 are separated by 21 nucleotides
Rv1162: Rv1162 - Probable respiratory nitrate reductase (beta chain) NarH, at 1,291,065 to 1,292,741
Rv1162
Rv1163: Rv1163 - Probable respiratory nitrate reductase (delta chain) NarJ, at 1,292,798 to 1,293,403
Rv1163
Rv1164: Rv1164 - Probable respiratory nitrate reductase (gamma chain) NarI, at 1,293,406 to 1,294,146
Rv1164
Rv1165: Rv1165 - Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein), at 1,294,168 to 1,296,054
Rv1165
Position (kb) 1292
1293
1294 Strain fitness (log2 ratio) -1
0
1
2
3 at 1291.891 kb on - strand, within Rv1162 at 1291.891 kb on - strand, within Rv1162 at 1291.944 kb on + strand, within Rv1162 at 1292.058 kb on + strand, within Rv1162 at 1292.095 kb on + strand, within Rv1162 at 1292.130 kb on + strand, within Rv1162 at 1292.241 kb on + strand, within Rv1162 at 1292.241 kb on + strand, within Rv1162 at 1292.320 kb on - strand, within Rv1162 at 1292.320 kb on - strand, within Rv1162 at 1292.397 kb on + strand, within Rv1162 at 1292.442 kb on + strand, within Rv1162 at 1292.442 kb on + strand, within Rv1162 at 1292.442 kb on + strand, within Rv1162 at 1292.443 kb on - strand, within Rv1162 at 1292.538 kb on + strand, within Rv1162 at 1292.539 kb on - strand, within Rv1162 at 1292.817 kb on + strand at 1292.818 kb on - strand at 1292.967 kb on - strand, within Rv1163 at 1293.005 kb on + strand, within Rv1163 at 1293.005 kb on + strand, within Rv1163 at 1293.006 kb on - strand, within Rv1163 at 1293.006 kb on - strand, within Rv1163 at 1293.006 kb on - strand, within Rv1163 at 1293.120 kb on - strand, within Rv1163 at 1293.120 kb on - strand, within Rv1163 at 1293.120 kb on - strand, within Rv1163 at 1293.318 kb on + strand, within Rv1163 at 1293.499 kb on + strand, within Rv1164 at 1293.538 kb on + strand, within Rv1164 at 1293.742 kb on + strand, within Rv1164 at 1293.802 kb on + strand, within Rv1164 at 1293.802 kb on + strand, within Rv1164 at 1293.927 kb on - strand, within Rv1164 at 1293.964 kb on + strand, within Rv1164 at 1293.965 kb on - strand, within Rv1164 at 1293.965 kb on - strand, within Rv1164 at 1293.965 kb on - strand, within Rv1164 at 1293.967 kb on + strand, within Rv1164 at 1293.968 kb on - strand, within Rv1164 at 1294.054 kb on + strand, within Rv1164 at 1294.070 kb on - strand, within Rv1164 at 1294.144 kb on + strand at 1294.144 kb on + strand at 1294.144 kb on + strand at 1294.145 kb on - strand at 1294.145 kb on - strand at 1294.383 kb on - strand, within Rv1165 at 1294.394 kb on + strand, within Rv1165 at 1294.395 kb on - strand, within Rv1165 at 1294.395 kb on - strand, within Rv1165 at 1294.395 kb on - strand, within Rv1165
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL remove 1,291,891 - Rv1162 0.49 -0.1 1,291,891 - Rv1162 0.49 -0.4 1,291,944 + Rv1162 0.52 +0.9 1,292,058 + Rv1162 0.59 -0.0 1,292,095 + Rv1162 0.61 -1.0 1,292,130 + Rv1162 0.64 -0.0 1,292,241 + Rv1162 0.70 +0.4 1,292,241 + Rv1162 0.70 +0.5 1,292,320 - Rv1162 0.75 +0.2 1,292,320 - Rv1162 0.75 -0.6 1,292,397 + Rv1162 0.79 -0.6 1,292,442 + Rv1162 0.82 -0.0 1,292,442 + Rv1162 0.82 -0.3 1,292,442 + Rv1162 0.82 +2.7 1,292,443 - Rv1162 0.82 -0.0 1,292,538 + Rv1162 0.88 -0.4 1,292,539 - Rv1162 0.88 -0.3 1,292,817 + +3.6 1,292,818 - -0.5 1,292,967 - Rv1163 0.28 -1.5 1,293,005 + Rv1163 0.34 -0.5 1,293,005 + Rv1163 0.34 -0.6 1,293,006 - Rv1163 0.34 -0.4 1,293,006 - Rv1163 0.34 +1.0 1,293,006 - Rv1163 0.34 -0.6 1,293,120 - Rv1163 0.53 +1.6 1,293,120 - Rv1163 0.53 -0.1 1,293,120 - Rv1163 0.53 -0.6 1,293,318 + Rv1163 0.86 -0.3 1,293,499 + Rv1164 0.13 +0.7 1,293,538 + Rv1164 0.18 +0.5 1,293,742 + Rv1164 0.45 -0.1 1,293,802 + Rv1164 0.53 -0.6 1,293,802 + Rv1164 0.53 -0.2 1,293,927 - Rv1164 0.70 +1.6 1,293,964 + Rv1164 0.75 +0.3 1,293,965 - Rv1164 0.75 +1.1 1,293,965 - Rv1164 0.75 -0.2 1,293,965 - Rv1164 0.75 +0.0 1,293,967 + Rv1164 0.76 -0.4 1,293,968 - Rv1164 0.76 +0.5 1,294,054 + Rv1164 0.87 -1.4 1,294,070 - Rv1164 0.90 +0.0 1,294,144 + -0.9 1,294,144 + -0.4 1,294,144 + +0.1 1,294,145 - -0.4 1,294,145 - +0.0 1,294,383 - Rv1165 0.11 -1.4 1,294,394 + Rv1165 0.12 -0.6 1,294,395 - Rv1165 0.12 -0.3 1,294,395 - Rv1165 0.12 -0.1 1,294,395 - Rv1165 0.12 +0.3
Or see this region's nucleotide sequence